Reactome | NDUFAF3 [mitochondrial inner membrane]

NDUFAF3 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5689126

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, NDUF3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75306 NDUFS2

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External Reference Information

External Reference

UniProt:Q9BU61 NDUFAF3

Gene Names

NDUFAF3, C3orf60

Chain

chain:1-184

Reference Genes

BioGPS Gene:25915 NDUFAF3

COSMIC (genes):NDUFAF3 NDUFAF3

CTD Gene:25915 NDUFAF3

dbSNP Gene:25915 NDUFAF3

ENSEMBL:ENSG00000178057 NDUFAF3

ENSEMBL_homo_sapiens_GENE:ENSG00000178057.15 NDUFAF3

HGNC:29918 NDUFAF3

KEGG Gene (Homo sapiens):25915 NDUFAF3

Monarch:25915 NDUFAF3

NCBI Gene:25915 NDUFAF3

OMIM:612911 NDUFAF3

UCSC:Q9BU61 NDUFAF3

Reference Transcript

RefSeq:NM_199069.1 NDUFAF3

Other Identifiers

11718411_a_at

11741452_a_at

16940642

209177_PM_at

209177_at

25915

2621951

2621952

2621953

2621955

2621957

2621958

2621960

2621962

2621964

2621965

34347_at

8079707

A_23_P256172

GE56214

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0007005

GO:0016020

GO:0032981

GO:0043226

GO:0065003

HMNXSV003047055

ILMN_1691557

ILMN_1702120

ILMN_2275560

ILMN_2354515

PH_hs_0031136

g12804040_3p_at

Participates

as an input of

IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

NDUFAF3 [mitochondrial inner membrane] (Bos taurus)

NDUFAF3 [mitochondrial inner membrane] (Canis familiaris)

NDUFAF3 [mitochondrial inner membrane] (Dictyostelium discoideum)

NDUFAF3 [mitochondrial inner membrane] (Gallus gallus)

NDUFAF3 [mitochondrial inner membrane] (Sus scrofa)

nuaf-3 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ndufaf3 [mitochondrial inner membrane] (Mus musculus)

Ndufaf3 [mitochondrial inner membrane] (Rattus norvegicus)

Dmel\CG5569 [mitochondrial inner membrane] (Drosophila melanogaster)

ndufaf3 [mitochondrial inner membrane] (Danio rerio)

ndufaf3 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_951032.1

OpenTargets

ENSG00000178057

GeneCards

Q9BU61

HPA

ENSG00000178057-NDUFAF3

Ensembl

ENSP00000323003, ENST00000395458, ENSG00000178057, ENST00000451378, ENST00000326925, ENSP00000323076, ENSP00000402465, ENSP00000378843, ENST00000326912

PRO

Q9BU61

Pharos - Targets

Q9BU61

Orphanet

18461

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.85	12
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.744	9
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.718	6
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.564	3
UniProt:Q8TAS1-2 UHMK1			0.556	3
UniProt:Q9NPB3 CABP2	1	CABP2 [plasma membrane] (R-HSA-9672352)	0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q9NTX7-2 RNF146			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	3
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.527	3
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.527	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.527	3
UniProt:Q9HBG6 IFT122	2	IFT122 [ciliary tip] (R-HSA-5625346) IFT122 [cilium] (R-HSA-5610379)	0.508	2

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