Reactome | NDUFAF5 [mitochondrial inner membrane]

NDUFAF5 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5689127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, NDUF5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P68871 HBB

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External Reference Information

External Reference

UniProt:Q5TEU4 NDUFAF5

Gene Names

NDUFAF5, C20orf7

Chain

transit peptide:1-36, chain:37-345

Reference Genes

BioGPS Gene:79133 NDUFAF5

COSMIC (genes):NDUFAF5 NDUFAF5

CTD Gene:79133 NDUFAF5

dbSNP Gene:79133 NDUFAF5

ENSEMBL:ENSG00000101247 NDUFAF5

HGNC:15899 NDUFAF5

KEGG:hsa:79133 NDUFAF5

Monarch:79133 NDUFAF5

NCBI Gene:79133 NDUFAF5

OMIM:612360 NDUFAF5

UCSC:Q5TEU4 NDUFAF5

Reference Transcript

Other Identifiers

11754489_a_at

16911525

219524_PM_s_at

219524_s_at

222894_PM_x_at

222894_x_at

227160_3p_s_at

227160_PM_s_at

227160_s_at

3877222

3877223

3877224

3877226

3877227

3877228

3877229

3877230

3877231

3877232

3877233

3877234

3877236

3877237

3877238

3877241

3877242

3877243

3877244

3877245

3877246

3877247

3877248

3877249

3877250

3877251

3877252

3877253

3877254

3877256

62140_at

62141_g_at

62142_i_at

62143_r_at

79133

8061019

A_24_P228579

A_24_P57847

GE88168

GO:0003674

GO:0003824

GO:0005515

GO:0005739

GO:0005743

GO:0008168

GO:0008757

GO:0016491

GO:0016740

GO:0030961

GO:0032259

GO:0032981

GO:0043226

GO:0065003

GO:0099617

HMNXSV003036483

HMNXSV003057621

Hs.44296.0.S1_3p_s_at

Hs.44296.1.S1_3p_at

ILMN_1718501

ILMN_1813344

ILMN_2262543

ILMN_2350607

PH_hs_0033263

TC20000095.hg

TC20001111.hg

g13129143_3p_s_at

Participates

as an input of

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ndufaf5 [mitochondrial inner membrane] (Danio rerio)

ndufaf5 [mitochondrial inner membrane] (Xenopus tropicalis)

Ndufaf5 [mitochondrial inner membrane] (Mus musculus)

Ndufaf5 [mitochondrial inner membrane] (Rattus norvegicus)

Dmel\CG8067 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFAF5 [mitochondrial inner membrane] (Bos taurus)

NDUFAF5 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFAF5 [mitochondrial inner membrane] (Canis familiaris)

NDUFAF5 [mitochondrial inner membrane] (Gallus gallus)

NDUFAF5 [mitochondrial inner membrane] (Sus scrofa)

Cross References

ENSEMBL

ENST00000463598, ENSP00000420497, ENSG00000101247, ENST00000378106, ENSP00000367346

OpenTargets

ENSG00000101247

GeneCards

NDUFAF5

HPA

ENSG00000101247-NDUFAF5

PRO

Q5TEU4

Pharos - Targets

Q5TEU4

Orphanet

NDUFAF5

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A1L188 NDUFAF8	1	NDUFAF8 [mitochondrion] (R-HSA-9906776)	0.748	11
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.643	5
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.615	4
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:Q8TAA5 GRPEL2	1	GRPEL2 [mitochondrial inner membrane] (R-HSA-1252076)	0.527	2
UniProt:O95299 NDUFA10	1	NDUFA10 [mitochondrial inner membrane] (R-HSA-163937)	0.527	2
UniProt:Q53GT1 KLHL22	1	KLHL22 [cytosol] (R-HSA-8863210)	0.527	3
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [extracellular region] (R-HSA-2168872) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:Q5BKU9 OXLD1			0.527	2
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.527	2
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:P14324 FDPS	1	FDPS [cytosol] (R-HSA-981566)	0.527	2

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