Reactome | MIA3 [endoplasmic reticulum membrane]

MIA3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5689472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

TANGO1

Locations in the PathwayBrowser for interactor UniProt:Q15436 SEC23A

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        MIA3 binds procollagen VII (Homo sapiens)
        
        MIA3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5JRA6 MIA3

Gene Names

MIA3, KIAA0268, TANGO, TANGO1, UNQ6077/PRO20088

Chain

signal peptide:1-22, chain:23-1907

Reference Genes

BioGPS Gene:375056 MIA3

COSMIC (genes):MIA3 MIA3

CTD Gene:375056 MIA3

dbSNP Gene:375056 MIA3

ENSEMBL:ENSG00000154305 MIA3

HGNC:24008 MIA3

KEGG:hsa:375056 MIA3

Monarch:375056 MIA3

NCBI Gene:375056 MIA3

OMIM:613455 MIA3

UCSC:Q5JRA6 MIA3

Reference Transcript

Participates

as a component of

as an input of

MIA3 binds procollagen VII (Homo sapiens)

Other forms of this molecule

MIA3 [endoplasmic reticulum lumen]

p-MIA3 [endoplasmic reticulum lumen]

Inferred To

Mia3 [endoplasmic reticulum membrane] (Mus musculus)

Mia3 [endoplasmic reticulum membrane] (Rattus norvegicus)

MIA3 [endoplasmic reticulum membrane] (Bos taurus)

MIA3 [endoplasmic reticulum membrane] (Canis familiaris)

MIA3 [endoplasmic reticulum membrane] (Gallus gallus)

MIA3 [endoplasmic reticulum membrane] (Sus scrofa)

Tango1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

mia3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001287796.1, NP_940953.2, NP_001310992.1

OpenTargets

ENSG00000154305

ENSEMBL

ENSP00000345866, ENSP00000340900, ENST00000344922, ENST00000340535, ENSG00000154305

HPA

ENSG00000154305-MIA3

GeneCards

MIA3

PRO

Q5JRA6

Pharos - Targets

Q5JRA6

GlyGen

Q5JRA6

PDB

5KYW, 5KYN, 5KYU, 7R3M

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UK55 SERPINA10	2	p-SERPINA10 [endoplasmic reticulum lumen] (R-HSA-8956990) SERPINA10 [endoplasmic reticulum lumen] (R-HSA-8956739)	0.564	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:O95833 CLIC3			0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	3
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.527	2
UniProt:Q8IW75 SPA12			0.527	2
UniProt:Q02388 COL7A1	20	3x4Hyp-3Hyp-5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605704) 5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605706) 3x4Hyp-3Hyp-COL7A1(2822-2944) [extracellular region] (R-HSA-3605690) 3x4Hyp-5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605707) 3x4Hyp-3Hyp-GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605709) COL7A1(2822-2944) [extracellular region] (R-HSA-3605694) 3x4Hyp-GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605696) 3x4Hyp-GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605698) 3x4Hyp-COL7A1(2822-2944) [extracellular region] (R-HSA-3605699) 3x4Hyp-3Hyp-GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605700) GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605687) GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605703) COL7A1 [extracellular region] (R-HSA-2127487) 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 [extracellular region] (R-HSA-2127471) GalHyl-COL7A1 [extracellular region] (R-HSA-2127517) 3x4Hyp-3Hyp-COL7A1 [extracellular region] (R-HSA-2127485) 3x4Hyp-COL7A1 [extracellular region] (R-HSA-2127530) 3x4Hyp-5Hyl-COL7A1 [extracellular region] (R-HSA-2127496) GlcGalHyl-COL7A1 [extracellular region] (R-HSA-2127478) 3x4Hyp-3Hyp-5Hyl-COL7A1 [extracellular region] (R-HSA-2127525)	0.524	2
UniProt:Q9BPX1 HSD17B14	1	HSD17B14 [cytosol] (R-HSA-6810587)	0.488	2

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