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TGFA precursor [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5689476
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Protransforming growth factor alpha, TGFA(24-160)
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
CNIH1 binds TFGA and AREG precursors (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
CNIH1 binds TFGA and AREG precursors (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH1:TFGA,AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
TGFA precursor [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01135 TGFA
Gene Names
TGFA
Chain
signal peptide:1-23, chain:24-160, propeptide:24-39, chain:40-89, propeptide:90-160
Reference Genes
BioGPS Gene:7039 TGFA
COSMIC (genes):TGFA TGFA
CTD Gene:7039 TGFA
dbSNP Gene:7039 TGFA
ENSEMBL:ENSG00000163235 TGFA
ENSEMBL_homo_sapiens_GENE:ENSG00000163235.16 TGFA
HGNC:11765 TGFA
KEGG Gene (Homo sapiens):7039 TGFA
Monarch:7039 TGFA
NCBI Gene:7039 TGFA
OMIM:190170 TGFA
UCSC:P01135 TGFA
Reference Transcript
RefSeq:NM_001099691.2 TGFA
RefSeq:NM_001308159.1 TGFA
RefSeq:NM_001308158.1 TGFA
RefSeq:NM_003236.3 TGFA
Other Identifiers
11728302_at
11728303_at
11745159_a_at
11745160_s_at
160025_at
16898788
205015_PM_s_at
205015_s_at
205016_PM_at
205016_at
211258_PM_s_at
211258_s_at
2558640
2558641
2558642
2558643
2558644
2558645
2558646
2558647
2558648
2558649
2558650
2558654
2558660
2558669
2558695
2558709
2558710
383_at
7039
8052872
A_23_P377291
A_33_P3408203
GE59968
GO:0000278
GO:0001525
GO:0005102
GO:0005154
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005789
GO:0005886
GO:0007173
GO:0008083
GO:0008284
GO:0009986
GO:0012507
GO:0016020
GO:0016323
GO:0023052
GO:0030297
GO:0030669
GO:0031410
GO:0033116
GO:0035556
GO:0036211
GO:0038134
GO:0043226
GO:0043410
GO:0045840
GO:0048018
GO:0048471
GO:0048856
GO:0050679
GO:0050731
GO:0051781
GO:0060749
GO:0072574
GO:0098772
GO:0140014
HMNXSV003001777
ILMN_1805175
ILMN_2083946
PH_hs_0010146
TC02001963.hg
X70340_at
g339537_3p_a_at
g4507460_3p_at
g6175597_3p_a_at
Participates
as an output of
TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)
TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)
as a member of
TFGA, AREG precursors [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
TGFA(24-98) [clathrin-coated endocytic vesicle membrane]
TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
TGFA precursor [ER to Golgi transport vesicle membrane]
TGFA(24-98) [extracellular region]
Inferred To
TGFA [endoplasmic reticulum membrane]
(Bos taurus)
TGFA [endoplasmic reticulum membrane]
(Canis familiaris)
TGFA [endoplasmic reticulum membrane]
(Sus scrofa)
TGFA precursor [endoplasmic reticulum membrane]
(Gallus gallus)
Tgfa [endoplasmic reticulum membrane]
(Mus musculus)
Tgfa [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001295088.1
,
NP_001093161.1
,
NP_003227.1
,
NP_001295087.1
OpenTargets
ENSG00000163235
GeneCards
P01135
HPA
ENSG00000163235-TGFA
Ensembl
ENST00000295400
,
ENSP00000295400
,
ENST00000418333
,
ENST00000445399
,
ENSG00000163235
,
ENSP00000404099
,
ENSP00000387493
PRO
P01135
Pharos - Targets
P01135
Orphanet
17254
HMDB Protein
HMDBP12416
PDB
7SZ7
,
1YUG
,
2TGF
,
1GK5
,
3E50
,
4TGF
,
5KN5
,
7SZ5
,
1YUF
,
3TGF
,
1MOX
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.779
4
UniProt:Q969F2 NKD2
0.573
3
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:Q9EQJ9 MAGI3
0.543
4
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