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BAP1 [nucleoplasm]
Stable Identifier
R-HSA-5689665
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin carboxyl-terminal hydrolase BAP1 ecNumber3.4.19.12/ecNumber, BAP1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q01167 FOXK2
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
BAP1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
BAP1 binds BAP1-interacting complex (Homo sapiens)
BAP1 [nucleoplasm] (Homo sapiens)
BAP1 binds BRCA1:BARD1 (Homo sapiens)
BAP1 [nucleoplasm] (Homo sapiens)
BAP1 binds Ub-HCFC1 (Homo sapiens)
BAP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92560 BAP1
Gene Names
BAP1, KIAA0272, hucep-6
Chain
chain:1-729
Reference Genes
BioGPS Gene:8314 BAP1
COSMIC (genes):BAP1 BAP1
CTD Gene:8314 BAP1
dbSNP Gene:8314 BAP1
ENSEMBL:ENSG00000163930 BAP1
HGNC:950 BAP1
KEGG:hsa:8314 BAP1
Monarch:8314 BAP1
NCBI Gene:8314 BAP1
OMIM:603089 BAP1
UCSC:Q92560 BAP1
Reference Transcript
RefSeq:NM_004656.3 BAP1
Other Identifiers
11717028_a_at
11717029_a_at
11747830_a_at
1555735_PM_a_at
1555735_a_at
16954770
201419_PM_at
201419_at
2676091
2676093
2676094
2676095
2676096
2676097
2676098
2676099
2676100
2676101
2676102
2676103
2676104
2676105
2676106
2676107
2676108
2676109
2676111
2676112
2676113
2676114
2676115
2676116
2676117
2676118
2676119
2676120
2676121
2676123
2676124
2676126
2676127
2676128
2676129
38682_at
8087885
8314
A_23_P259012
A_24_P302898
D87462_at
GE54395
GO:0000278
GO:0001558
GO:0001701
GO:0001894
GO:0002376
GO:0002574
GO:0003677
GO:0003682
GO:0003824
GO:0004843
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006355
GO:0006508
GO:0006511
GO:0008233
GO:0008234
GO:0008283
GO:0008285
GO:0010467
GO:0012501
GO:0016579
GO:0016787
GO:0030154
GO:0030218
GO:0030223
GO:0030851
GO:0031490
GO:0033028
GO:0035517
GO:0035520
GO:0035726
GO:0036211
GO:0036344
GO:0043226
GO:0043249
GO:0043363
GO:0045892
GO:0048856
GO:0050727
GO:0051726
GO:0061484
GO:0061519
GO:0070050
GO:0070661
GO:0071108
GO:0140096
GO:0140950
GO:1900015
GO:1903955
HMNXSV003014949
Hs2.106674.2.S1_3p_s_at
ILMN_1768363
PH_hs_0005935
TC03001453.hg
TC03002916.hg
g4757835_3p_at
Participates
as a component of
BAP1:BAP1-interacting complex [nucleoplasm] (Homo sapiens)
BAP1:HCFC1 [nucleoplasm] (Homo sapiens)
BAP1:K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (Homo sapiens)
PR-DUB core complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1:BAP1 [nucleoplasm] (Homo sapiens)
BAP1:BARD1 [nucleoplasm] (Homo sapiens)
as an input of
BAP1 binds BAP1-interacting complex (Homo sapiens)
BAP1 binds BRCA1:BARD1 (Homo sapiens)
BAP1 binds Ub-HCFC1 (Homo sapiens)
BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
Inferred To
caly [nucleoplasm]
(Drosophila melanogaster)
uch2 [nucleoplasm]
(Dictyostelium discoideum)
uch2 [nucleoplasm]
(Schizosaccharomyces pombe)
bap1 [nucleoplasm]
(Danio rerio)
bap1 [nucleoplasm]
(Xenopus tropicalis)
BAP1 [nucleoplasm]
(Bos taurus)
BAP1 [nucleoplasm]
(Canis familiaris)
BAP1 [nucleoplasm]
(Gallus gallus)
BAP1 [nucleoplasm]
(Sus scrofa)
Bap1 [nucleoplasm]
(Mus musculus)
Bap1 [nucleoplasm]
(Rattus norvegicus)
UCH54 [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
NP_004647.1
Guide to Pharmacology - Targets
2332
ENSEMBL
ENST00000460680
,
ENSP00000417132
OpenTargets
ENSG00000163930
HPA
ENSG00000163930-BAP1
PRO
Q92560
Pharos - Targets
Q92560
GlyGen
Q92560
Orphanet
BAP1
PDB
8H1T
,
8SVF
,
7VPW
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IXJ9 ASXL1
1
ASXL1 [nucleoplasm]
(R-HSA-5689645)
0.832
9
UniProt:P51610 HCFC1
2
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
HCFC1 [nucleoplasm]
(R-HSA-1592209)
0.744
6
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.725
5
UniProt:Q01167 FOXK2
1
FOXK2 [nucleoplasm]
(R-HSA-5689655)
0.725
6
UniProt:Q76L83 ASXL2
1
ASXL2 [nucleoplasm]
(R-HSA-5689629)
0.643
5
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.643
5
UniProt:Q8NB78 KDM1B
1
KDM1B [nucleoplasm]
(R-HSA-5423072)
0.643
4
UniProt:Q9C0C9 UBE2O
1
UBE2O [cytosol]
(R-HSA-947641)
0.643
4
UniProt:Q14573 ITPR3
2
ITPR3 [endoplasmic reticulum membrane]
(R-HSA-169690)
ITPR3 [platelet dense tubular network membrane]
(R-HSA-418283)
0.64
12
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.543
3
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.527
3
UniProt:Q8IWZ3 ANKH1
0.527
2
UniProt:Q9Y5Z7 HCFC2
1
HCFC2 [nucleoplasm]
(R-HSA-9821232)
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.488
2
UniProt:Q9ULV8 CBLC
0.488
2
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