Reactome | TIMMDC1 [mitochondrial inner membrane]

TIMMDC1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5689720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Complex I assembly factor TIMMDC1, mitochondrial, TIDC1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P51572 BCAP31

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External Reference Information

External Reference

UniProt:Q9NPL8 TIMMDC1

Gene Names

TIMMDC1, C3orf1, UNQ247/PRO284

Chain

chain:1-285

Reference Genes

BioGPS Gene:51300 TIMMDC1

COSMIC (genes):TIMMDC1 TIMMDC1

CTD Gene:51300 TIMMDC1

dbSNP Gene:51300 TIMMDC1

ENSEMBL:ENSG00000113845 TIMMDC1

ENSEMBL_homo_sapiens_GENE:ENSG00000113845.10 TIMMDC1

HGNC:1321 TIMMDC1

KEGG Gene (Homo sapiens):51300 TIMMDC1

Monarch:51300 TIMMDC1

NCBI Gene:51300 TIMMDC1

OMIM:615534 TIMMDC1

UCSC:Q9NPL8 TIMMDC1

Reference Transcript

RefSeq:NM_016589.3 TIMMDC1

Other Identifiers

11757279_a_at

16944386

223004_PM_s_at

223004_s_at

227546_PM_x_at

2638018

2638019

2638020

2638021

2638025

2638026

2638028

2638029

2638032

2638034

2638037

2638038

2638039

49192_s_at

51300

8081867

A_14_P118040

A_14_P132374

A_23_P18413

GE54904

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0016020

GO:0031966

GO:0043226

HMNXSV003051924

Hs.76239.3.A1_3p_s_at

ILMN_2193175

PH_hs_0023057

TC03000609.hg

g12003267_3p_a_at

Participates

as an input of

IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

Timmdc1 [mitochondrial inner membrane] (Mus musculus)

Timmdc1 [mitochondrial inner membrane] (Rattus norvegicus)

TIMMDC1 [mitochondrial inner membrane] (Bos taurus)

TIMMDC1 [mitochondrial inner membrane] (Caenorhabditis elegans)

TIMMDC1 [mitochondrial inner membrane] (Canis familiaris)

TIMMDC1 [mitochondrial inner membrane] (Gallus gallus)

TIMMDC1 [mitochondrial inner membrane] (Sus scrofa)

timmdc1 [mitochondrial inner membrane] (Danio rerio)

timmdc1 [mitochondrial inner membrane] (Xenopus tropicalis)

140up [mitochondrial inner membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_057673.2

OpenTargets

ENSG00000113845

GeneCards

Q9NPL8

HPA

ENSG00000113845-TIMMDC1

Ensembl

ENST00000494664, ENSP00000418803, ENSG00000113845

PRO

Q9NPL8

Pharos - Targets

Q9NPL8

Orphanet

24983

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969F0 FATE1			0.666	4
UniProt:Q9NX14 NDUFB11	1	NDUFB11 [mitochondrial inner membrane] (R-HSA-163933)	0.666	4
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.643	5
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.643	4
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.643	5
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.643	5
UniProt:Q9NX47 MARH5			0.556	3
UniProt:Q96HP8 T176A			0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q9Y225-2 RNF24			0.556	3
UniProt:Q6PI78 TMM65			0.556	3
UniProt:Q8WVX3-2 C4ORF3			0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q969K7 TMM54			0.556	3
UniProt:Q8N6R1 SERP2			0.556	3
UniProt:Q86Y82 STX12			0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q8TAZ6 CKLF2			0.556	3
UniProt:Q16849-3 PTPRN			0.556	3
UniProt:Q6UW88-2 Q6UW882			0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:O75063 XYLK			0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:Q6ICL7 S35E4			0.556	3
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.556	3
UniProt:P50542-3 PEX5			0.556	3
UniProt:Q6UWT4 CE046			0.556	3
UniProt:Q8N6S5 AR6P6			0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:O95236-2 APOL3			0.556	3
UniProt:Q92982 NINJ1			0.556	3
UniProt:Q8TD06 AGR3			0.556	3
UniProt:Q9HCS2 CYP4F12	1	CYP4F12 [endoplasmic reticulum membrane] (R-HSA-211015)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:P01563 IFNA2	1	IFNA2 [extracellular region] (R-HSA-877349)	0.556	3
UniProt:Q9Y548 YIPF1			0.556	3
UniProt:Q8N511 TM199			0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:Q8N357 S35F6			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q86WB7-2 UNC93A			0.556	3
UniProt:Q8N912 NRAC			0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q96PD2-2 DCBLD2			0.556	3
UniProt:Q5SR56 MF14B			0.556	3
UniProt:Q8N682 DRAM1			0.556	3
UniProt:Q96JF0-2 ST6GAL2			0.556	3
UniProt:O75920 SERF1			0.556	3
UniProt:Q7Z5S9 TM144			0.556	3
UniProt:Q07326 PIGF	1	PIGF [endoplasmic reticulum membrane] (R-HSA-162819)	0.556	3
UniProt:Q9NYZ1 TV23B			0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.556	3
UniProt:Q99706 KIR2DL4	1	KIR2DL4 [plasma membrane] (R-HSA-197726)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.527	2
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.527	2
UniProt:O95298 NDUFC2	3	NDUFC2 [plasma membrane] (R-HSA-6806276) NDUFC2 [azurophil granule membrane] (R-HSA-6799211) NDUFC2 [mitochondrial inner membrane] (R-HSA-59860)	0.527	2
UniProt:Q8IUX1 TMEM126B	1	TMEM126B [mitochondrial inner membrane] (R-HSA-5689046)	0.527	2
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	2
UniProt:Q9BU61 NDUFAF3	1	NDUFAF3 [mitochondrial inner membrane] (R-HSA-5689126)	0.527	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	3
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.527	3
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	4

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