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(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-HSA-5689730
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Synonyms
Cathepsin Z
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBR2 CTSZ
Gene Names
CTSZ
Chain
signal peptide:1-23, propeptide:24-61, chain:62-303
Reference Genes
BioGPS Gene:1522 CTSZ
COSMIC (genes):CTSZ CTSZ
CTD Gene:1522 CTSZ
dbSNP Gene:1522 CTSZ
ENSEMBL:ENSG00000101160 CTSZ
HGNC:2547 CTSZ
KEGG:hsa:1522 CTSZ
Monarch:1522 CTSZ
NCBI Gene:1522 CTSZ
OMIM:603169 CTSZ
UCSC:Q9UBR2 CTSZ
Reference Transcript
RefSeq:NM_001336.3 CTSZ
Other Identifiers
11726594_at
1522
16920762
210042_PM_s_at
210042_s_at
3205250
32514_s_at
3911751
3911753
3911754
3911756
3911758
3911760
3911762
3911764
3911766
3911768
3911769
3911770
3911771
3911772
3911773
3911774
3911775
3911776
3911778
3911779
3911780
3911781
3911782
3911783
3911784
3946555
61829_at
8067279
A_23_P40240
A_33_P3250398
GE475635
GE816852
GO:0002003
GO:0003824
GO:0004180
GO:0004197
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005886
GO:0005938
GO:0006508
GO:0008234
GO:0010757
GO:0016787
GO:0030134
GO:0030312
GO:0031012
GO:0031410
GO:0033116
GO:0035580
GO:0043226
GO:0043231
GO:0051603
GO:0051604
GO:0060441
GO:0062023
GO:0070062
GO:0140096
GO:1904813
HMNXSV003014927
HMNXSV003039493
ILMN_1666269
PH_hs_0013327
TC20000992.hg
TC20001680.hg
g3650497_3p_at
p28622
p33806
Participates
as a member of
glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Other forms of this molecule
CTSZ [specific granule lumen]
CTSZ [extracellular region]
CTSZ [ficolin-1-rich granule lumen]
(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen]
(Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle]
CTSZ [plasma membrane]
CTSZ [lysosomal lumen]
CTSZ [Golgi lumen]
Inferred To
(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Gallus gallus)
Ctsz [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Mus musculus)
Ctsz [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Rattus norvegicus)
CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Bos taurus)
CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Canis familiaris)
CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Sus scrofa)
cpz-1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Caenorhabditis elegans)
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position
Modification
N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Cross References
Guide to Pharmacology - Targets
2354
OpenTargets
ENSG00000101160
ENSEMBL
ENSP00000217131
,
ENST00000217131
HPA
ENSG00000101160-CTSZ
ZINC - Substances
CATZ_HUMAN
ZINC target
Q9UBR2
PRO
Q9UBR2
Pharos - Targets
Q9UBR2
GlyGen
Q9UBR2
ZINC - Predictions - Purchasable
CATZ_HUMAN
PDB
1DEU
,
1EF7
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.83
8
UniProt:Q9UJV3-2 MID2
0.718
6
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.666
4
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q63HR2 TENS2
0.556
3
UniProt:Q9BYR9 KRTAP2-4
1
KRTAP2-4 [cytosol]
(R-HSA-6809951)
0.556
3
UniProt:Q9BYV9 BACH2
0.556
3
UniProt:Q5TD97 FHL5
0.556
3
UniProt:Q9BYR6 KRTAP3-3
1
KRTAP3-3 [cytosol]
(R-HSA-6809859)
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
IntAct:EBI-16436789 CCSB ORF ID
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:O15162 PLS1
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:P60014 KRTAP10-10
1
KRTAP10-10 [cytosol]
(R-HSA-6810293)
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
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