Reactome | CNIH2 [ER to Golgi transport vesicle membrane]

CNIH2 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-5689780

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

ERV14

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2 [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6PI25 CNIH2

Gene Names

CNIH2, CNIL

Chain

chain:1-160

Reference Genes

BioGPS Gene:254263 CNIH2

COSMIC (genes):CNIH2 CNIH2

CTD Gene:254263 CNIH2

dbSNP Gene:254263 CNIH2

ENSEMBL:ENSG00000174871 CNIH2

HGNC:28744 CNIH2

KEGG:hsa:254263 CNIH2

Monarch:254263 CNIH2

NCBI Gene:254263 CNIH2

OMIM:611288 CNIH2

UCSC:Q6PI25 CNIH2

Reference Transcript

RefSeq:NM_182553.2 CNIH2

Other Identifiers

11724426_a_at

16727363

230070_PM_at

230070_at

254263

3336095

3336096

3336097

3336098

3336099

3336100

3336101

3336102

3336103

3336104

3336105

3336106

3336108

3336110

48415_at

7941587

A_14_P131794

A_24_P203315

GE568548

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0012507

GO:0014069

GO:0016020

GO:0016192

GO:0030425

GO:0032281

GO:0033116

GO:0042995

GO:0043197

GO:0043198

GO:0043226

GO:0045202

GO:0045211

GO:2000311

HMNXSV003018648

Hs.19487.0.A1_3p_at

ILMN_1698733

ILMN_1762802

ILMN_1808903

ILMN_2349696

PH_hs_0020636

PH_hs_0038023

TC11000658.hg

Participates

as a member of

CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

CNIH2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

CNIH2 [endoplasmic reticulum membrane]

Inferred To

cni-1 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

cnih2 [ER to Golgi transport vesicle membrane] (Danio rerio)

cnih2 [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

Cnih2 [ER to Golgi transport vesicle membrane] (Mus musculus)

Cnih2 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

RAB1B [ER to Golgi transport vesicle membrane] (Bos taurus)

CNIH2 [ER to Golgi transport vesicle membrane] (Canis familiaris)

cni [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000310003, ENST00000311445

OpenTargets

ENSG00000174871

HPA

ENSG00000174871-CNIH2

PRO

Q6PI25

Pharos - Targets

Q6PI25

PDB

8SS7, 8SS6, 8SS4, 8SSA, 8SS3, 8SS2, 8SSB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3

Cite Us!