Reactome | CNIH3 [ER to Golgi transport vesicle membrane]

CNIH3 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-5689783

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CNIH3 [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TBE1 CNIH3

Gene Names

CNIH3

Chain

chain:1-160

Reference Genes

BioGPS Gene:149111 CNIH3

COSMIC (genes):CNIH3 CNIH3

CTD Gene:149111 CNIH3

dbSNP Gene:149111 CNIH3

ENSEMBL:ENSG00000143786 CNIH3

ENSEMBL_homo_sapiens_GENE:ENSG00000143786.8 CNIH3

HGNC:26802 CNIH3

KEGG Gene (Homo sapiens):149111 CNIH3

Monarch:149111 CNIH3

NCBI Gene:149111 CNIH3

UCSC:Q8TBE1 CNIH3

Reference Transcript

RefSeq:NM_152495.1 CNIH3

Other Identifiers

11727045_at

149111

214841_PM_at

214841_at

2382529

2382530

2382548

2382552

2382564

2382565

2382567

2382568

34942_at

7910022

A_14_P100311

A_23_P384044

GE514176

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0012507

GO:0016020

GO:0016192

GO:0023052

GO:0030425

GO:0031410

GO:0032281

GO:0033116

GO:0043198

GO:0043226

GO:0045202

GO:0045211

GO:0055085

GO:2000311

Hs.13410.0.S1_3p_at

ILMN_1749071

PH_hs_0024602

Participates

as a member of

CNIH2,3 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

CNIH3 [endoplasmic reticulum-Golgi intermediate compartment membrane]

CNIH3 [endoplasmic reticulum membrane]

Inferred To

cni-1 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

CNIH3 [ER to Golgi transport vesicle membrane] (Bos taurus)

CNIH3 [ER to Golgi transport vesicle membrane] (Canis familiaris)

CNIH3 [ER to Golgi transport vesicle membrane] (Gallus gallus)

CNIH3 [ER to Golgi transport vesicle membrane] (Sus scrofa)

Cnih3 [ER to Golgi transport vesicle membrane] (Mus musculus)

Cnih3 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

cnih3 [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

cni [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_689708.1

OpenTargets

ENSG00000143786

HPA

ENSG00000143786-CNIH3

GeneCards

Q8TBE1

Ensembl

ENST00000272133, ENSG00000143786, ENSP00000272133

PRO

Q8TBE1

Pharos - Targets

Q8TBE1

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) OPTN [Golgi membrane] (R-HSA-2161111) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.556	3

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