USP5 cleaves polyubiquitin

Stable Identifier
R-HSA-5690152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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USP5 cleaves polyubiquitin
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP5 (Isopeptidease T) cleaves linear and branched polyubiquitin (polyUb) with a preference for branched polymers (Wilkonson et al. 1995). It is Involved in the disassembly of unattached lysine-48-linked (K48) polyUb. It also binds linear and K63-linked polyUb with a lower affinity (Dayal et al. 2009).
Literature References
PubMed ID Title Journal Year
7578059 Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

Tashayev, VL, Pickart, CM, Wilkinson, KD, O'Connor, LB, Larsen, CN, Kasperek, E

Biochemistry 1995
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Output
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Catalyst Activity

cysteine-type deubiquitinase activity of USP5:PolyUb [cytosol]

Physical Entity
USP5:PolyUb [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP5 cleaves polyubiquitin (Bos taurus)
USP5 cleaves polyubiquitin (Canis familiaris)
USP5 cleaves polyubiquitin (Danio rerio)
USP5 cleaves polyubiquitin (Dictyostelium discoideum)
USP5 cleaves polyubiquitin (Drosophila melanogaster)
USP5 cleaves polyubiquitin (Gallus gallus)
USP5 cleaves polyubiquitin (Mus musculus)
USP5 cleaves polyubiquitin (Rattus norvegicus)
USP5 cleaves polyubiquitin (Schizosaccharomyces pombe)
USP5 cleaves polyubiquitin (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-27)
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