Reactome | USP8 deubiquitinates RNF128

USP8 deubiquitinates RNF128

Stable Identifier

R-HSA-5690196

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ubiquitin E3 ligase RNF128 (GRAIL) is regulated by auto-K48-linked ubiquitination, which leads to its proteasomal degradation. RNF128 is bound but not deubiquitinated by OTUB1. USP8 binds the RNF128:OTUB1 complex to remove the ubiquitin attached to GRAIL (Soares et al. 2004, Whiting et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
14661020	Two isoforms of otubain 1 regulate T cell anergy via GRAIL Skrenta, H, Lovelace, P, Seroogy, C, Engleman, E, Soares, L, Chung, CD, Anandasabapathy, N, Fathman, CG	Nat. Immunol.	2004