p-T182-MAPKAPK5 phoshphorylates DNAJB1

Stable Identifier
R-HSA-5690250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-T182-MAPKAPK5 phoshphorylates DNAJB1
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Activated MAPKAPK5 phosphorylates HSP40/DNAJB1 at serines 149, 151 and 171, promoting the ATP hydrolysis activity of the HSP40/HSP70 complex and enhancing the repression of heat shock factor 1 (HSF1) driven transcription by HSP40/DNAJB1 (Kostenko et al, 2014).
Literature References
PubMed ID Title Journal Year
24309468 Phosphorylation of heat shock protein 40 (Hsp40/DnaJB1) by mitogen-activated protein kinase-activated protein kinase 5 (MK5/PRAK)

Jensen, KL, Kostenko, S, Moens, U

Int. J. Biochem. Cell Biol. 2014
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Catalyst Activity

protein serine/threonine kinase activity of p-T182 MAPKAPK5:DNAJB1 [cytosol]

Physical Entity
p-T182 MAPKAPK5:DNAJB1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)
Authored
Moens, U  (2015-04-24)
Reviewed
Moens, U  (2015-04-24)
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Seternes, OM  (2015-05-05)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-04-27)
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