Reactome | p-T182-MAPKAPK5 phoshphorylates DNAJB1

p-T182-MAPKAPK5 phoshphorylates DNAJB1

Stable Identifier

R-HSA-5690250

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated MAPKAPK5 phosphorylates HSP40/DNAJB1 at serines 149, 151 and 171, promoting the ATP hydrolysis activity of the HSP40/HSP70 complex and enhancing the repression of heat shock factor 1 (HSF1) driven transcription by HSP40/DNAJB1 (Kostenko et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24309468	Phosphorylation of heat shock protein 40 (Hsp40/DnaJB1) by mitogen-activated protein kinase-activated protein kinase 5 (MK5/PRAK) Jensen, KL, Kostenko, S, Moens, U	Int. J. Biochem. Cell Biol.	2014