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NAc-CD22 [plasma membrane]
Stable Identifier
R-HSA-5690736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
N-acetylneuraminic acid-CD22, Sialic acid-CD22
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
CD22 mediated BCR regulation (Homo sapiens)
CD22 binds itself to form homo-oligomers (Homo sapiens)
NAc-CD22 [plasma membrane] (Homo sapiens)
NAc-CD22 homo-oligomer [plasma membrane] (Homo sapiens)
NAc-CD22 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20273 CD22
Gene Names
CD22, SIGLEC2
Chain
signal peptide:1-19, chain:20-847
Reference Genes
BioGPS Gene:933 CD22
COSMIC (genes):CD22 CD22
CTD Gene:933 CD22
dbSNP Gene:933 CD22
ENSEMBL:ENSG00000012124 CD22
ENSEMBL:ENSG00000012124.17 CD22
HGNC:1643 CD22
KEGG Gene (Homo sapiens):933 CD22
Monarch:933 CD22
NCBI Gene:933 CD22
OMIM:107266 CD22
UCSC:P20273 CD22
Reference Transcript
RefSeq:NM_001185100.1 CD22
RefSeq:NM_001771.3 CD22
RefSeq:NM_001185099.1 CD22
RefSeq:NM_001278417.1 CD22
RefSeq:NM_001185101.1 CD22
Other Identifiers
11726290_a_at
11754830_a_at
16860992
204581_PM_at
204581_at
217422_3p_s_at
217422_PM_s_at
217422_s_at
3830349
3830350
3830352
3830354
3830366
3830368
3830369
3830370
3830371
3830373
3830375
3830376
3830378
3830379
3830381
3830385
3830388
3830390
3830391
3830393
3830394
3830395
3830396
3830405
3830407
3830409
38521_PM_at
38521_at
38522_s_at
4853636C_3p_s_at
52277_at
8027837
933
A_14_P131478
A_23_P209055
GE81067
GO:0001791
GO:0002376
GO:0002638
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0007155
GO:0009897
GO:0009986
GO:0016020
GO:0016192
GO:0019903
GO:0023052
GO:0030100
GO:0030246
GO:0030888
GO:0031410
GO:0032809
GO:0033691
GO:0042113
GO:0042609
GO:0043226
GO:0050776
GO:0050849
GO:0050859
GO:0055037
GO:0070062
HMNXSV003039199
Hs.171763.1.S1_3p_s_at
ILMN_1792075
PH_hs_0023308
TC19002611.hg
X59350_at
g4502650_3p_at
g4502650_3p_s_at
Participates
as a repeated unit of
NAc-CD22 homo-oligomer [plasma membrane] (Homo sapiens)
as an input of
CD22 binds itself to form homo-oligomers (Homo sapiens)
Other forms of this molecule
CD22 [plasma membrane]
p-Y762,807,822-CD22 [plasma membrane]
Inferred To
cd22 [plasma membrane]
(Xenopus tropicalis)
NAc-CD22 [plasma membrane]
(Canis familiaris)
NAc-CD22 [plasma membrane]
(Mus musculus)
Cd22 [plasma membrane]
(Rattus norvegicus)
CD22 [plasma membrane]
(Bos taurus)
CD22 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
N-acetylneuraminylated at 65
Coordinate
65
PsiMod Name
N-acetylneuraminylated
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond.
Cross References
RefSeq
NP_001762.2
,
NP_001265346.1
,
NP_001172030.1
,
NP_001172029.1
,
NP_001172028.1
Guide to Pharmacology - Targets
2786
OpenTargets
ENSG00000012124
ZINC - Substances
CD22_HUMAN
ZINC target
P20273
PRO
P20273
PDB
5VL3
,
7O52
,
5VKM
,
5VKJ
GeneCards
P20273
HPA
ENSG00000012124-CD22
Ensembl
ENSP00000441237
,
ENSP00000085219
,
ENST00000536635
,
ENSG00000012124
,
ENST00000419549
,
ENST00000085219
,
ENST00000544992
,
ENST00000341773
,
ENST00000594250
,
ENSP00000403822
,
ENSP00000469984
,
ENSP00000442279
,
ENSP00000339349
Pharos - Targets
P20273
ZINC - Predictions - Purchasable
CD22_HUMAN
HMDB Protein
HMDBP14330
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.623
4
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
LYN [cytosol]
(R-HSA-354251)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
0.499
2
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [plasma membrane]
(R-HSA-167682)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.499
2
UniProt:P29350 PTPN6
5
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.499
4
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