BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1

Stable Identifier
R-HSA-5690759
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth (Eletr & Wilinson 2011), though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated; the major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).

Literature References
PubMed ID Title Journal Year
19815555 The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1

Machida, YJ, Machida, Y, Vashisht, AA, Wohlschlegel, JA, Dutta, A

J. Biol. Chem. 2009
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of BAP1:K48polyUb,K63polyUb-HCFC1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!