TNFAIP3 (A20) ubiquitinates RIPK1

Stable Identifier
R-HSA-5690827
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TNFAIP3 (A20) ubiquitinates RIPK1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The carboxy-terminal domain of TNFAIP3 (A20) functions as a ubiquitin ligase, polyubiquitinating RIPK1 with K48-linked ubiquitin chains, thereby targeting it for proteasomal degradation (Wertz et al. 2004).
Literature References
PubMed ID Title Journal Year
15258597 De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

Dixit, VM, Koonin, EV, Eby, M, Aravind, L, Ma, A, O'Rourke, KM, Baker, R, Boone, DL, Wertz, IE, Wu, P, Seshagiri, S, Zhou, H, Wiesmann, C

Nature 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of TNFAIP3:RIPK1 [cytosol]

Physical Entity
TNFAIP3:RIPK1 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)
TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-30)
Cite Us!