TNIPs bind TNFAIP3 (A20)

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TNFAIP3-interacting protein (TNIPs), also known as A20-binding inhibitors of NF-kappa-B activation (ABINs), bind TNFAIP3, the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein A20 (Heyninck et al. 1999). Overexpression of TNIPs inhibits NF-kappaB activation by tumor necrosis factor (TNF). TNIPs have a ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities. They may function as adaptors between ubiquitinated proteins and other regulatory proteins, or disrupt signaling complexes by competing with other ubiquitin-binding proteins (Verstrepen et al. 2009).

Literature References
PubMed ID Title Journal Year
10385526 The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

Vanden Berghe, W, Haegeman, G, De Valck, D, Heyninck, K, Van Criekinge, W, Beyaert, R, Contreras, R, Fiers, W

J. Cell Biol. 1999
19464428 ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

Beyaert, R, Verhelst, K, Verstrepen, L, Carpentier, I

Biochem. Pharmacol. 2009
Orthologous Events
Cite Us!