Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex containing the F-box/LRR-repeat protein 5 (FBXL5) protein (SKP1:FBXL5:CUL1:NEDD8) targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Cullin-1 (CUL1) is in neddylated form (NEDD8) which allows it to associate with this complex.
Leibold, EA, Sun, D, Sangfelt, O, Bhaskaran, N, Powers, DN, Huang, X, Wohlschlegel, JA, Spruck, C, Durazo, A, Vashisht, AA, Zumbrennen, KB, Uhlén, M, Persson, A
Ma, HW, Salahudeen, AA, Kinch, LN, Ruiz, JC, Li, Q, Grishin, NV, Bruick, RK, Thompson, JW
ubiquitin-protein transferase activity of SKP1:FBXL5:CUL1:NEDD8 [cytosol]
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