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HFE [plasma membrane]
Stable Identifier
R-HSA-5691126
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hereditary hemochromatosis protein precursor, HFE_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
HFE binds TFRC dimer (Homo sapiens)
HFE [plasma membrane] (Homo sapiens)
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
HFE [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q30201 HFE
Gene Names
HFE, HLAH
Chain
signal peptide:1-22, chain:23-348
Reference Genes
BioGPS Gene:3077 HFE
COSMIC (genes):HFE HFE
CTD Gene:3077 HFE
dbSNP Gene:3077 HFE
ENSEMBL:ENSG00000010704 HFE
HGNC:4886 HFE
KEGG:hsa:3077 HFE
Monarch:3077 HFE
NCBI Gene:3077 HFE
OMIM:613609 HFE
UCSC:Q30201 HFE
Reference Transcript
RefSeq:NM_139003.2 HFE
RefSeq:NM_139006.2 HFE
RefSeq:NM_000410.3 HFE
RefSeq:NM_139009.2 HFE
RefSeq:NM_001300749.1 HFE
RefSeq:NM_139007.2 HFE
RefSeq:NM_139011.2 HFE
RefSeq:NM_139010.2 HFE
RefSeq:NM_139004.2 HFE
RefSeq:NM_139008.2 HFE
Other Identifiers
11736346_a_at
11736347_x_at
11736348_a_at
11741480_x_at
11742265_a_at
11751543_x_at
11753161_a_at
11759416_x_at
11763027_x_at
1553402_PM_a_at
1553402_a_at
17005542
206086_3p_x_at
206086_PM_x_at
206086_x_at
206087_PM_x_at
206087_x_at
210864_PM_x_at
210864_x_at
211326_3p_x_at
211326_PM_x_at
211326_x_at
211327_PM_x_at
211327_x_at
211328_PM_x_at
211328_x_at
211329_PM_x_at
211329_x_at
211330_PM_s_at
211330_s_at
211331_PM_x_at
211331_x_at
211332_PM_x_at
211332_x_at
211863_3p_x_at
211863_PM_x_at
211863_x_at
211866_3p_x_at
211866_PM_x_at
211866_x_at
214647_PM_s_at
214647_s_at
235754_PM_at
235754_at
2899113
2899114
2899115
2899116
2899117
2899118
2899119
2899120
2899121
2899125
2899126
2899127
2899128
2899129
2899130
2899131
2899132
2899133
2899134
2899135
2899136
2899137
2899138
2899139
2899140
2899141
2899142
2899143
3077
38913_at
50508_at
50664_at
80609_at
8117343
A_14_P116363
A_23_P145204
A_23_P342009
A_24_P103448
A_24_P111996
A_24_P289648
A_24_P354748
GE497653
GE59270
GO:0001916
GO:0002376
GO:0002476
GO:0002486
GO:0002725
GO:0005102
GO:0005515
GO:0005615
GO:0005654
GO:0005768
GO:0005769
GO:0005886
GO:0006826
GO:0006879
GO:0009897
GO:0010039
GO:0010628
GO:0016020
GO:0030509
GO:0030881
GO:0031410
GO:0032092
GO:0032435
GO:0034756
GO:0039706
GO:0042446
GO:0043226
GO:0045177
GO:0045178
GO:0048260
GO:0048471
GO:0055037
GO:0060391
GO:0060586
GO:0065003
GO:0071281
GO:0090277
GO:1900121
GO:1900122
GO:1904283
GO:1904434
GO:1904437
GO:1990459
GO:1990641
GO:1990712
GO:2000008
GO:2000059
GO:2000272
GO:2000273
GO:2001186
HMNXSV003019111
HMNXSV003024221
Hs.107216.0.A1_3p_at
Hs.20019.12.S2_3p_a_at
ILMN_1683345
ILMN_1743537
ILMN_2263236
ILMN_2302632
PH_hs_0023171
TC06000165.hg
TC06002643.hg
U60319_at
g11093523_3p_s_at
g11093523_3p_x_at
g11093525_3p_a_at
g11093525_3p_at
g11093525_3p_x_at
g11094314_3p_a_at
g11094320_3p_a_at
g11094320_3p_x_at
g11094322_3p_x_at
g11094324_3p_a_at
g11094326_3p_a_at
g11094326_3p_x_at
g11094328_3p_x_at
g3695108_3p_a_at
g3695110_3p_a_at
g4504376_3p_x_at
Participates
as a component of
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
as an input of
HFE binds TFRC dimer (Homo sapiens)
Inferred To
mhc1zda [plasma membrane]
(Danio rerio)
mhc1zea [plasma membrane]
(Danio rerio)
mhc1-uba15 [plasma membrane]
(Xenopus tropicalis)
mhc1zca [plasma membrane]
(Danio rerio)
Hfe [plasma membrane]
(Mus musculus)
Hfe [plasma membrane]
(Rattus norvegicus)
mhc1uba [plasma membrane]
(Danio rerio)
LOC100490728 [plasma membrane]
(Xenopus tropicalis)
mhc1zba [plasma membrane]
(Danio rerio)
mhc1zfa [plasma membrane]
(Danio rerio)
Homologues of HFE [plasma membrane]
(Danio rerio)
Homologues of HFE [plasma membrane]
(Gallus gallus)
Homologues of HFE [plasma membrane]
(Xenopus tropicalis)
BF1 [plasma membrane]
(Gallus gallus)
HFE [plasma membrane]
(Bos taurus)
HFE [plasma membrane]
(Canis familiaris)
HFE [plasma membrane]
(Gallus gallus)
HFE [plasma membrane]
(Sus scrofa)
mhc1uma [plasma membrane]
(Danio rerio)
BFIV21 [plasma membrane]
(Gallus gallus)
mhc1-uda [plasma membrane]
(Xenopus tropicalis)
mhc1-uea [plasma membrane]
(Xenopus tropicalis)
mhc1-uba13.5 [plasma membrane]
(Xenopus tropicalis)
mhc1laa [plasma membrane]
(Danio rerio)
mr1l [plasma membrane]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000010704
ENSEMBL
ENSP00000315936
,
ENSP00000417404
,
ENST00000352392
,
ENST00000488199
,
ENSP00000313776
,
ENST00000397022
,
ENSG00000010704
,
ENSP00000312342
,
ENST00000349999
,
ENSP00000259699
,
ENST00000353147
,
ENST00000461397
,
ENSP00000337819
,
ENST00000357618
,
ENST00000317896
,
ENSP00000380217
,
ENSP00000420559
,
ENSP00000420802
,
ENST00000336625
HPA
ENSG00000010704-HFE
GeneCards
HFE
PRO
Q30201
Pharos - Targets
Q30201
Orphanet
HFE
GlyGen
Q30201
PDB
1A6Z
,
1DE4
HMDB Protein
HMDBP01659
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [plasma membrane]
(R-HSA-167743)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
0.734
5
UniProt:P02786 TFRC
5
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
0.621
3
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