PSMD14 cleaves K63-linked ubiquitin

Stable Identifier
R-HSA-5691431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PSMD14 cleaves K63-linked ubiquitin
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PSMD14 (RPN11, POH1) is a subunit of the proteasomal 19S lid complex that specifically cleaves Lysine-63-linked polyubiquitin chains (Yao & Cohen 2002, Butler et al. 2012).

Literature References
PubMed ID Title Journal Year
12353037 A cryptic protease couples deubiquitination and degradation by the proteasome

Cohen, RE, Yao, T

Nature 2002
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Catalyst Activity

Lys63-specific deubiquitinase activity of PSMD14 [cytosol]

Physical Entity
PSMD14 [cytosol] (Homo sapiens)
Activity
Lys63-specific deubiquitinase activity (GO:0061578)
Orthologous Events
PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)
PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)
PSMD14 cleaves K63-linked ubiquitin (Danio rerio)
PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)
PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)
PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)
PSMD14 cleaves K63-linked ubiquitin (Mus musculus)
PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)
PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)
PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)
PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-05-07)
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