Reactome | ADH5 oxidises S-HMGSH to S-FGSH

ADH5 oxidises S-HMGSH to S-FGSH

Stable Identifier

R-HSA-5692237

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Alcohol dehydrogenase class-3 (ADH5) is a cytosolic dimeric enzyme that binds 2 Zn2+ per subunit. It is very ineffective in oxidising ethanol, but it readily catalyses the oxidation of S-(hydroxymethyl) glutathione (S-HMGSH) to S-formylglutathione (S-FGSH) (Kaiser et al. 1988, Julia et al. 1988) as well as the oxidation of long-chain primary alcohols (not shown here).

Literature References

PubMed ID	Title	Journal	Year
3278908	Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases Pareś, X, Jörnvall, H, Julià, P	Eur. J. Biochem.	1988
3365377	Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes Kaiser, R, Holmquist, B, Jörnvall, H, Vallee, BL, Hempel, J	Biochemistry	1988