Reactome | SEPT7 [cytosol]

SEPT7 [cytosol]

Stable Identifier

R-HSA-5692671

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q8IYM1 SEP12

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External Reference Information

External Reference

UniProt:Q16181 SEPTIN7

Gene Names

SEPTIN7, CDC10, SEPT7

Chain

initiator methionine:1, chain:2-437

Reference Genes

BioGPS Gene:989 SEPTIN7

COSMIC (genes):SEPT7 SEPTIN7

CTD Gene:989 SEPTIN7

dbSNP Gene:989 SEPTIN7

ENSEMBL:ENSG00000122545 SEPTIN7

HGNC:1717 SEPTIN7

KEGG:hsa:989 SEPTIN7

Monarch:989 SEPTIN7

NCBI Gene:989 SEPTIN7

OMIM:603151 SEPTIN7

UCSC:Q16181 SEPTIN7

Reference Transcript

Participates

as an input of

SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)

as a component of

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)

Inferred To

SEPTIN7 [cytosol] (Canis familiaris)

SEPTIN7 [cytosol] (Gallus gallus)

SEPTIN7 [cytosol] (Sus scrofa)

spn1 [cytosol] (Schizosaccharomyces pombe)

septin7a [cytosol] (Danio rerio)

pnut [cytosol] (Drosophila melanogaster)

CDC3 [cytosol] (Saccharomyces cerevisiae)

Septin7 [cytosol] (Mus musculus)

Septin7 [cytosol] (Rattus norvegicus)

unc-59 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001011553.2, NP_001779.3, XP_047277051.1

OpenTargets

ENSG00000122545

ENSEMBL

ENST00000705486, ENSG00000122545, ENSP00000516132, ENSP00000344868, ENST00000350320

HPA

ENSG00000122545-SEPTIN7

GeneCards

SEPTIN7

PRO

Q16181

Pharos - Targets

Q16181

GlyGen

Q16181

PDB

6N12, 7M6J, 2QAG, 6UQQ, 3T5D, 8SJJ, 3TW4, 6N0B

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15019 SEPTIN2	1	SEPT2 [cytosol] (R-HSA-5626657)	0.86	14
UniProt:Q14141 SEPT6			0.848	8
UniProt:Q9NVA2 SEP11			0.8	6
UniProt:Q9UHD8 SEPT9			0.768	7
UniProt:Q92599 SEPT8			0.744	6
UniProt:Q99719 SEPT5			0.738	5
UniProt:Q8IYM1 SEP12			0.734	19
UniProt:Q15019-1 SEPTIN2			0.728	8
UniProt:Q9P0V9 SEP10			0.669	4
UniProt:Q9UH03 SEPT3			0.643	5
UniProt:Q16181 SEPTIN7	1	SEPT7 [cytosol] (R-HSA-5692671)	0.558	2
UniProt:Q6ZU15 SEP14			0.547	2
UniProt:O43236 SEPTIN4			0.527	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.527	2
UniProt:P42208	1	Septin2 [cytosol] (R-MMU-5626657)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	7
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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