Reactome | MAPK6 binds CCND3

MAPK6 binds CCND3

Stable Identifier

R-HSA-5692764

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MAPK6 interacts with Cyclin D3 (CCND3) through its C-terminal extension, and this interaction is stabilized by overexpression of CDC14 phosphatase (Sun et al, 2006; Hansen et al, 2008). Although the physiological relevance of the interaction between MAPK6 and CCND3 is not known, both proteins regulate cell cycle entry and MAPK6 is stabilized during differentiation and upon inhibition of proliferation (Coulombe et al, 2003; Bartkova et al, 1998; Julien et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
9747882	Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation Bartkova, J, Lukas, J, Strauss, M, Bartek, J	Oncogene	1998
18235225	A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3 Hansen, CA, Bartek, J, Jensen, S	Cell Cycle	2008
12915405	Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression Julien, C, Coulombe, P, Meloche, S	J. Biol. Chem.	2003
12808096	Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation Coulombe, P, Rodier, G, Pelletier, S, Pellerin, J, Meloche, S	Mol. Cell. Biol.	2003
16360641	Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3 Sun, M, Wei, Y, Yao, L, Xie, J, Chen, X, Wang, H, Jiang, J, Gu, J	Biochem. Biophys. Res. Commun.	2006