Reactome | SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

Stable Identifier

R-HSA-5692770

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

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SEPT7 forms a ternary complex with MAPK6 and MAPKAPK5 that contributes to neuronal development through the phosphorylation of the Binders of RHO GTPase (BORG) proteins (Brand et al, 2012). Septins are cytoskeletal GTP-binding proteins that form filaments and contribute to processes such as cytokinesis, cell polarity and cell division, among others (reviewed in Spiliotis and Nelson, 2006). Interaction of septin proteins with the CDC42 effector proteins 2, 3 and 5 (CDC42EP2, 3, 5; also known as BORG1, 2 and 3) inhibits formation of septin filaments (Jouberty et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11584266	Borg proteins control septin organization and are negatively regulated by Cdc42 Perlungher, RR, Joberty, G, Macara, IG, Kinoshita, M, Sheffield, PJ, Haystead, T, Noda, M	Nat. Cell Biol.	2001
16371649	Here come the septins: novel polymers that coordinate intracellular functions and organization Spiliotis, ET, Nelson, WJ	J. Cell. Sci.	2006
22508986	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology Schumacher, S, Brand, F, Kant, S, Meloche, S, Kotlyarov, A, Gaestel, M, Menon, MB, Turgeon, B, Simon, R, Britsch, S	Mol. Cell. Biol.	2012