p-S215 FOXO1 binds RAG gene

Stable Identifier
R-HSA-5692785
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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p-S215 FOXO1 binds RAG gene
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After phosphorylation by MAPKAPK5, p-S215 FOXO1 binds to the RAG gene promoter to promote transcription (Lin et al, 2010; Ochiai et al, 2012; Chow et al, 2013).

Literature References
PubMed ID Title Journal Year
20543837 A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

Benner, C, Glass, CK, Murre, C, Hagman, J, Heinz, S, Mansson, R, Dutkowski, J, Ideker, T, Sigvardsson, M, Welinder, E, Lin, YC, Jhunjhunwala, S, Espinoza, CA

Nat. Immunol. 2010
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
22267219 A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

Bertolino, E, Mandal, M, Singh, H, Triggs, JR, Ochiai, K, Dinner, AR, Maienschein-Cline, M, Clark, MR, Sciammas, R

Nat. Immunol. 2012
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Authored
Meloche, S  (2015-05-12)
Reviewed
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-05-12)
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