p-S215 FOXO1 binds RAG gene

Stable Identifier
R-HSA-5692785
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S215 FOXO1 binds RAG gene
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After phosphorylation by MAPKAPK5, p-S218 FOXO1 binds to the RAG gene promoter to promote transcription (Lin et al, 2010; Ochiai et al, 2012; Chow et al, 2013).
Literature References
PubMed ID Title Journal Year
20543837 A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

Lin, YC, Jhunjhunwala, S, Benner, C, Heinz, S, Welinder, E, Mansson, R, Sigvardsson, M, Hagman, J, Espinoza, CA, Dutkowski, J, Ideker, T, Glass, CK, Murre, C

Nat. Immunol. 2010
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
22267219 A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

Ochiai, K, Maienschein-Cline, M, Mandal, M, Triggs, JR, Bertolino, E, Sciammas, R, Dinner, AR, Clark, MR, Singh, H

Nat. Immunol. 2012
Participants
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Output
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Authored
Meloche, S  (2015-05-12)
Reviewed
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-05-13)
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