p-S215 FOXO1 positively regulates RAG gene expression

Stable Identifier
R-HSA-5692794
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S215 FOXO1 positively regulates RAG gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of p-S215 FOXO1 to the RAG genes promotes expression of RAG proteins, which are required for V(D)J recombination (Chow et al, 2013).
Literature References
PubMed ID Title Journal Year
23878308 MK5 activates Rag transcription via Foxo1 in developing B cells

Chow, KT, Timblin, GA, McWhirter, SM, Schlissel, MS

J. Exp. Med. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S215 FOXO1:RAG1,2 gene [nucleoplasm] (Homo sapiens)
Authored
Meloche, S  (2015-05-12)
Reviewed
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-05-13)
Cite Us!