Reactome | GGA1 [endosome membrane]

GGA1 [endosome membrane]

Stable Identifier

R-HSA-5692930

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

ADP-ribosylation factor-binding protein GGA1, GGA1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UJY5 GGA1

Gene Names

GGA1

Chain

chain:1-639

Reference Genes

BioGPS Gene:26088 GGA1

COSMIC (genes):GGA1 GGA1

CTD Gene:26088 GGA1

dbSNP Gene:26088 GGA1

ENSEMBL:ENSG00000100083 GGA1

HGNC:17842 GGA1

KEGG:hsa:26088 GGA1

Monarch:26088 GGA1

NCBI Gene:26088 GGA1

OMIM:606004 GGA1

UCSC:Q9UJY5 GGA1

Reference Transcript

Participates

as a member of

GGA1,2,3 [endosome membrane] (Homo sapiens)

Other forms of this molecule

GGA1 [early endosome membrane]

Cross References

RefSeq

NP_001350700.1, NP_037497.1, XP_024307983.1, XP_006724292.1, NP_001001560.1, XP_016884251.1, XP_047297282.1, XP_005261577.1, XP_016884250.1, XP_024307984.1, XP_047297280.1, XP_047297281.1, XP_011528424.1, XP_016884249.1, NP_001166158.1, NP_001166159.1, XP_005261574.1

OpenTargets

ENSG00000100083

ENSEMBL

ENST00000325180, ENSP00000520500, ENSP00000385287, ENSP00000341344, ENSP00000321288, ENST00000343632, ENST00000381756, ENSG00000100083, ENSP00000371175, ENST00000715689, ENST00000406772

HPA

ENSG00000100083-GGA1

GeneCards

GGA1

PRO

Q9UJY5

Pharos - Targets

Q9UJY5

GlyGen

Q9UJY5

HMDB Protein

HMDBP08420

PDB

3G2W, 1OM9, 1JWG, 2DWX, 3G2S, 1NWM, 2DWY, 1J2J, 1PY1, 1NA8, 3G2V, 1X79, 1JWF, 1UJK, 1NAF, 1UJJ, 1O3X, 1OXZ, 3G2T, 3G2U

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.744	5
UniProt:P56817 BACE1	8	BACE1 [endosome membrane] (R-HSA-5692942) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326)	0.668	4
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.581	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.558	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.544	2
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.544	2
UniProt:P84080	2	ARF1 [cytosol] (R-BTA-200826) ARF1 [Golgi membrane] (R-BTA-199971)	0.527	2
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.527	3
UniProt:P51790 CLCN3	1	CLCN3 [late endosome membrane] (R-HSA-2671918)	0.527	3
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.519	6
UniProt:Q9NZ52 GGA3	3	GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [endosome membrane] (R-HSA-5692936)	0.508	4