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BACE1:GGA1,2,3 translocates from plasma membrane to endosome
Stable Identifier
R-HSA-5692941
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)
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Beta-secretase 1 (BACE1, memapsin-2) mediates the proteolytic processing of amyloid precursor protein (APP). BACE1 is transported from the cell surface to endosomes where APP hydrolysis takes place. The acid-cluster-dileucine (ACDL) motif in the cytosolic domain of BACE1 is able to bind to the VHS domain of ADP-ribosylation factor-binding proteins 1, 2 and 3 (GGA1,2,3) which play a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. This is the presumed recognition step for BACE1 transport to endosomes (He et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
14567678
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins
Zhu, G
,
Rodgers, KK
,
Koelsch, G
,
Tang, J
,
Zhang, XC
,
He, X
Biochemistry
2003
Participants
Input
BACE1:GGA1,2,3 [plasma membrane]
(Homo sapiens)
Output
BACE1 [endosome membrane]
(Homo sapiens)
GGA1,2,3 [endosome membrane]
(Homo sapiens)
Participates
as an event of
Amyloid fiber formation (Homo sapiens)
Authored
Jassal, B (2015-05-13)
Reviewed
D'Eustachio, P (2015-06-26)
Perry, G (2015-11-09)
Created
Jassal, B (2015-05-13)
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