Reactome | 7K-BACE1(46-501) [Golgi-associated vesicle lumen]

7K-BACE1(46-501) [Golgi-associated vesicle lumen]

Stable Identifier

R-HSA-5693106

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi-associated vesicle lumen

Synonyms

Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN

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External Reference Information

External Reference

UniProt:P56817 BACE1

Gene Names

BACE1, BACE, KIAA1149

Chain

signal peptide:1-21, propeptide:22-45, chain:46-501

Reference Genes

BioGPS Gene:23621 BACE1

COSMIC (genes):BACE1 BACE1

CTD Gene:23621 BACE1

dbSNP Gene:23621 BACE1

ENSEMBL:ENSG00000186318 BACE1

ENSEMBL_homo_sapiens_GENE:ENSG00000186318.18 BACE1

HGNC:933 BACE1

KEGG Gene (Homo sapiens):23621 BACE1

Monarch:23621 BACE1

NCBI Gene:23621 BACE1

OMIM:604252 BACE1

UCSC:P56817 BACE1

Reference Transcript

Other Identifiers

11716390_a_at

11716391_a_at

11749940_a_at

11753657_a_at

11753658_x_at

11754653_a_at

16744822

217904_PM_s_at

217904_s_at

222462_PM_s_at

222462_s_at

222463_PM_s_at

222463_s_at

224335_PM_s_at

224335_s_at

23621

3393256

3393258

3393259

3393260

3393261

3393262

3393263

3393264

3393265

3393267

3393268

3393270

3393273

3393276

3393277

3393279

3393280

3393281

3393282

3393284

3393295

3393296

3393297

3393298

44849_at

45790_at

7951910

A_33_P3240936

A_33_P3240941

GE58458

GO:0001540

GO:0003824

GO:0004175

GO:0004190

GO:0005515

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005771

GO:0005773

GO:0005783

GO:0005788

GO:0005794

GO:0005802

GO:0005886

GO:0006508

GO:0006509

GO:0008021

GO:0008233

GO:0008798

GO:0009986

GO:0010008

GO:0010288

GO:0012501

GO:0016020

GO:0016485

GO:0016787

GO:0019899

GO:0023052

GO:0030424

GO:0030425

GO:0030659

GO:0031410

GO:0034205

GO:0042987

GO:0042995

GO:0043025

GO:0043226

GO:0043525

GO:0045121

GO:0050435

GO:0050804

GO:0050877

GO:0050966

GO:0051604

GO:0055037

GO:0060134

GO:0070931

GO:0071280

GO:0071287

GO:0098686

GO:0098793

GO:0099171

GO:0140096

GO:0140448

GO:1904646

GO:1990000

HMNXSV003025985

HMNXSV003046053

Hs.49349.0.S3_3p_a_at

ILMN_1797804

ILMN_2320349

PH_hs_0003439

TC11002335.hg

TC11003367.hg

TC11003368.hg

g13568406_3p_s_at

g6118538_3p_a_at

g6912265_3p_a_at

p2517

Participates

as an output of

FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)

as an input of

Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)

Other forms of this molecule

BACE1 [endoplasmic reticulum lumen]

7K-BACE1 [endoplasmic reticulum lumen]

BACE1(22-45) [Golgi-associated vesicle lumen]

7K-BACE1 [Golgi-associated vesicle lumen]

BACE1(46-501) [Golgi-associated vesicle lumen]

BACE1(46-501) [plasma membrane]

BACE1 [endosome membrane]

Modified Residues

Name

N6-acetyl-L-lysine at 126

Coordinate

126

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 275

Coordinate

275

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 279

Coordinate

279

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 285

Coordinate

285

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 299

Coordinate

299

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 300

Coordinate

300

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Name

N6-acetyl-L-lysine at 307

Coordinate

307

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_620427.1, NP_620429.1, NP_001193978.1, NP_620428.1, NP_036236.1

ZINC - World Drugs

BACE1_HUMAN

Guide to Pharmacology - Targets

2330

OpenTargets

ENSG00000186318

ZINC - FDA approved

BACE1_HUMAN

ZINC - Substances

BACE1_HUMAN

ZINC - Biogenic

BACE1_HUMAN

ZINC target

P56817

PRO

P56817

PDB

4LXA, 6WNY, 4J17, 3SKG, 4BEK, 3L5F, 3RU1, 7D36, 5QDC, 1XS7, 2FDP, 2QU3, 4B00, 4I0J, 4WY1, 3S2O, 3INF, 3OHH, 1YM4, 2Q11, 2VNN, 5QD8, 3UDH, 4PZW, 5EZZ, 7F1D, 6NV7, 6DHC, 1TQF, 2VJ6, 4ACU, 2VA7, 5MXD, 6UWP, 4FS4, 6NW3, 4JPC, 4J0Z, 4GMI, 6JSN, 4B78, 3R1G, 5HDZ, 3UQP, 5CLM, 4J1E, 5QDA, 2QMD, 2VJ9, 4LXM, 4I10, 5QCY, 2ZJJ, 5QD7, 3U6A, 3MSJ, 3UDR, 2P4J, 4H3J, 7DCZ, 4IVT, 5T1W, 4R5N, 4FGX, 5QCW, 5QD5, 2WF0, 4DH6, 2NTR, 2VA5, 4DPF, 5ENK, 5QCT, 3VF3, 4AZY, 4X2L, 1M4H, 4ZPE, 3UDM, 1UJK, 6BFX, 4TRZ, 5I3X, 5YGY, 4H3G, 6JSF, 3LPJ, 3OOZ, 4R95, 2IRZ, 3EXO, 2XFK, 4XKX, 4RRN, 2OHN, 4J1I, 5QCV, 6BFD, 4KE0, 3FKT, 2OHQ, 3UDP, 2VIY, 3HW1, 4YBI, 4K9H, 4FRI, 5MCQ, 2ZHT, 5HDV, 3L5C, 4JOO, 4ZPG, 4B72, 4J0V, 3IND, 6DMI, 1W50, 6UWV, 6JT3, 4D88, 5V0N, 5F01, 3RSX, 4DV9, 3INH, 2PH6, 5QD3, 4EWO, 4I1C, 2QP8, 4XXS, 5HE7, 3WB5, 5QCR, 3DV1, 4LC7, 2VKM, 2VIE, 3LNK, 5HD0, 3UQW, 6UVP, 5KR8, 2G94, 2ZJH, 2HIZ, 3S7L, 7B1Q, 4L7J, 3TPP, 4I0H, 6C2I, 4RCF, 4TRW, 3RTM, 3N4L, 4D8C, 4B1C, 4J1F, 2ZE1, 5MBW, 3CKR, 3BUG, 2F3F, 2QZK, 3L59, 6EJ2, 2WF3, 4DJV, 7MYI, 7N66, 3IN4, 2XFI, 3CID, 5QDD, 5HU0, 5QCO, 4DJX, 3H0B, 3L5D, 2VJ7, 6NV9, 3TPJ, 3UDJ, 2ZHR, 4B05, 5QCP, 4I0D, 4D83, 4B1E, 3IXJ, 4I0F, 4RCD, 3UQR, 7D5A, 3L38, 5QDB, 2OHT, 5I3V, 3RVI, 5QD1, 4H1E, 2Q15, 4FM7, 3K5F, 4ZSQ, 2ZJM, 2OHL, 4BFD, 5HE4, 3MSK, 2P8H, 4L7G, 2OAH, 4KE1, 2OHR, 4FRS, 3QBH, 5QD6, 4PZX, 7D2V, 3IVH, 4LXK, 3VV6, 4DPI, 3CIB, 6FGY, 3RTN, 3VEU, 4ZSM, 4FRJ, 3LPK, 4J0P, 3KYR, 3UDY, 2HM1, 3ZMG, 4R8Y, 3VG1, 2VIZ, 3OHF, 2QU2, 4WY6, 5I3Y, 6BFE, 3VV8, 4I11, 4ACX, 2ZHU, 2WF1, 3SKF, 6E3Z, 4J1C, 3KN0, 5TOL, 3L5E, 4JPE, 3KMX, 2QMF, 3R2F, 3INE, 4FSE, 5ENM, 1XN2, 3BRA, 4H3I, 3K5C, 4IVS, 4X7I, 5HDX, 5QD9, 2ZJK, 4J0Y, 5QCZ, 2VNM, 5QCX, 4RRO, 4D89, 4ZPF, 4HZT, 5QD4, 2QK5, 1W51, 3BUH, 5EZX, 2QZL, 6EJ3, 4H3F, 2PH8, 5I3W, 2OHP, 4J1K, 3RTH, 2VA6, 4R92, 3UDQ, 3DM6, 4K8S, 2ZJI, 1PY1, 7B1E, 6JSG, 1YM2, 6PZ4, 2VIJ, 5UYU, 1FKN, 4J0T, 3IGB, 6UVV, 2WF4, 3L5B, 3WB4, 5HDU, 4DI2, 2B8L, 4JP9, 3LPI, 6JT4, 2OF0, 5T1U, 4R91, 2IS0, 4I0Z, 4B77, 4I12, 4D85, 2WJO, 5HU1, 2XFJ, 2IQG, 3DV5, 3RSV, 3KMY, 3HVG, 1XN3, 6JSE, 6EQM, 2OHM, 4J1H, 4WTU, 3NSH, 5QCS, 2OHU, 3UQX, 4FCO, 2WF2, 6BFW, 5YGX, 4RRS, 3L58, 3TPR, 5IE1, 3IXK, 5MCO, 3UDN, 2ZJN, 2ZHS, 4RCE, 4I0I, 5QCU, 3K5G, 5QD2, 4ZSR, 2F3E, 4TRY, 4B70, 2ZDZ, 4EXG, 7MYR, 3CKP, 3BUF, 3L3A, 4R93, 4GID, 3S7M, 4DUS, 2B8V, 3PI5, 3VV7, 4B0Q, 2P83, 2OHK, 4ZSP, 7D2X, 2OHS, 3IVI, 3CIC, 3IN3, 2QMG, 3ZOV, 4HA5, 4FRK, 5F00, 4B1D, 4DJU, 5QCQ, 3LHG, 3UQU, 4I0E, 5DQC, 7B1P, 3QI1, 5HE5, 6OD6, 2ZHV, 5HTZ, 4DJW, 4I0G, 1SGZ, 2WEZ, 3I25, 5KQF, 3TPL, 4DJY, 3UDK, 2ZJL, 4DVF, 3MSL, 4FM8, 6UVY, 4FSL, 3DUY, 1UJJ, 3K5D, 4N00, 3UFL, 4L7H, 5QD0, 7MYU

ZINC - Investigational

BACE1_HUMAN

ZINC - Metabolites

BACE1_HUMAN

HPA

ENSG00000186318-BACE1

GeneCards

P56817

Ensembl

ENSG00000186318, ENSP00000422461, ENST00000513780, ENSP00000424536, ENSP00000318585, ENST00000428381, ENST00000510630, ENSP00000402228, ENST00000392937, ENSP00000475405, ENST00000313005, ENST00000445823, ENSP00000403685

Pharos - Targets

P56817

ZINC - Predictions - Purchasable

BACE1_HUMAN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.865	11
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.668	4
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.639	6
UniProt:P10997 IAPP	2	IAPP(1-89) [cytosol] (R-HSA-186631) IAPP(34-70) [extracellular region] (R-HSA-420076)	0.558	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.556	4
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.544	2
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [early endosome membrane] (R-HSA-8854137)	0.544	2
UniProt:Q03721 KCNC4	1	KCNC4 [plasma membrane] (R-HSA-977458)	0.524	3
UniProt:Q8BNX1	1	Clec4g [plasma membrane] (R-MMU-1472852)	0.524	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.454	3

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