CEMIP hydrolyses HA

Stable Identifier
R-HSA-5693356
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The cell migration-inducing and hyaluronan-binding protein CEMIP (KIAA1199) is able to depolymerise high molecular weight hyaluronic acid (HA) polymers into intermediate-sized products. It randomly hydrolyses of 1-4 linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues of HA. CEMIP may play a key role in HA catabolism in the dermis of the skin and arthritic synovium (Yoshida et al. 2013).
Literature References
PubMed ID Title Journal Year
23509262 KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

Inoue, S, Kusaka-Kikushima, A, Sayo, T, Sakai, S, Yoshida, H, Tobiishi, M, Sugiyama, Y, Okada, Y, Kawabata, K, Nagaoka, A, Enomoto, H

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participates
Catalyst Activity

hyalurononglucosaminidase activity of CEMIP [extracellular region]

Orthologous Events
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