HSD17B11 dehydrogenates EST17b to E1

Stable Identifier
R-HSA-5693390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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HSD17B11 dehydrogenates EST17b to E1
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Estradiol 17-beta-dehydrogenase 11 (HSD17B11) may participate in androgen metabolism during steroidogenesis where it dehydrogenates estradiol-17-beta (EST17b) to estrone (E1) (Chai et al. 2003).
Literature References
PubMed ID Title Journal Year
12697717 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells

Sasano, H, Suzuki, T, Krozowski, Z, Fuller, P, Escher, G, Chai, Z, Enriquez, C, Brereton, P, Saffery, R, Obeyesekere, V

Endocrinology 2003
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Output
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Event Information
Reverse Reaction
HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)
Catalyst Activity

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B11 [cytosol]

Physical Entity
HSD17B11 [cytosol] (Homo sapiens)
Activity
estradiol 17-beta-dehydrogenase [NAD(P)+] activity (GO:0004303)
Orthologous Events
HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)
HSD17B11 dehydrogenates EST17b to E1 (Gallus gallus)
HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)
HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)
HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)
HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)
HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-15)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-15)
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