Reactome | Phosphorylation of BRCA1-A complex at multiple sites by ATM

Phosphorylation of BRCA1-A complex at multiple sites by ATM

Stable Identifier

R-HSA-5693551

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of BRCA1-A complex at multiple sites by ATM

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ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1457, and S1524 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16651405	DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex Fonseca, D, Li, H, Cevher, M, Kleiman, FE, Lee, SB, Kim, HS, Parmelee, A	Cancer Res.	2006
11114888	Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Tibbetts, RS, Abraham, RT, Cortez, D, Livingston, D, Brumbaugh, KM, Elledge, SJ, Scully, R	Genes Dev.	2000
10866324	Role for ATM in DNA damage-induced phosphorylation of BRCA1 Weber, B, Scott, SP, Lavin, MF, Filippovitch, I, Khanna, KK, Soronika, N, Gatei, M	Cancer Res.	2000
10550055	Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks Elledge, SJ, Wang, Y, Cortez, D, Qin, J	Science	1999

Participants

Input

Output

Participates

as an event of

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm]

Physical Entity

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

Phosphorylation of BRCA1 (Gallus gallus)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)

Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)