Reactome | ATM phosphorylates NBN

ATM phosphorylates NBN

Stable Identifier

R-HSA-5693598

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NSB1 (NBN) is a component of the MRN (MRE11:RAD50:NBN) complex which acts early in homologous recombination repair (HRR) during recognition and resection of double-strand breaks (DSBs). ATM-mediated phosphorylation of NBN at serine residue S343 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR (Lim et al. 2000, Gatei et al. 2000, Lee and Paull 2004). The phosphorylation of NBN by ATM may be enhanced by the presence of BRCA1 (Foray et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10802669	ATM-dependent phosphorylation of nibrin in response to radiation exposure Spring, K, Lavin, MF, Concannon, P, Gatti, RA, Desai-Mehta, A, Khanna, K, Cerosaletti, KM, Young, D, Gatei, M, Kozlov, S	Nat. Genet.	2000
10766245	ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway Kastan, MB, Lim, DS, Petrini, JH, Xu, B, Kim, ST, Lin, J, Maser, RS	Nature	2000
15064416	Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex Lee, JH, Paull, TT	Science	2004
12773400	A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Ashworth, A, Jeggo, P, Perricaudet, M, Gabriel, A, Randrianarison, V, Foray, N, Marot, D	EMBO J	2003