Reactome | ATM phosphorylates TP53 at S15

ATM phosphorylates TP53 at S15

Stable Identifier

R-HSA-5693609

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        ATM phosphorylates TP53 at S15 (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATM phosphorylates TP53 at S15 (Homo sapiens)

General

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SVG | | PPTX | SBGN

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In response to DNA double strand breaks, serine at position 15 of the TP53 (p53) tumor suppressor protein is rapidly phosphorylated by the ATM kinase. This serves to stabilize the p53 protein. A rise in the levels of the p53 protein induces the expression of p21 cyclin-dependent kinase inhibitor. This prevents the normal progression from G1 to S phase, thus providing a check on replication of damaged DNA (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9843217	ATM associates with and phosphorylates p53: mapping the region of interaction. Gatei, M, Hobson, K, Taya, Y, Kozlov, S, Scott, S, Keating, KE, Lees-Miller, SP, Lavin, MF, Gabrielli, B, Khanna, KK, Chan, D	Nat Genet	1998
9733515	Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Appella, E, Siliciano, JD, Kastan, MB, Tamai, K, Taya, Y, Sakaguchi, K, Lim, DS, Canman, CE	Science	1998
9733514	Enhanced phosphorylation of p53 by ATM in response to DNA damage. Shiloh, Y, Taya, Y, Reiss, Y, Ziv, Y, Smorodinsky, NI, Prives, C, Anderson, CW, Chessa, L, Moyal, L, Shieh, S, Banin, S	Science	1998