Reactome | DUOX1,2 reduce O2 to H2O2

DUOX1,2 reduce O2 to H2O2

Stable Identifier

R-HSA-5693681

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

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Dual oxidases 1 and 2 (DUOX1, 2) mediates the generation of hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase for thyroid hormone formation and lactoperoxidase (Edens et al. 2001, Ameziane-El-Hassani et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
11514595	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox Kinkade, JM, Lee, T, Edens, WA, Shapira, R, Edens, HA, Benian, GM, Sullards, C, Cheng, G, Lambeth, JD, Tang, X, Flaherty, DB, Sharling, L	J. Cell Biol.	2001
15972824	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity Apostolou, D, Noël-Hudson, MS, Boucher, JL, Ameziane-El-Hassani, R, Morand, S, Lalaoui, K, Ohayon, R, Agnandji, D, Frapart, YM, Dupuy, C, Gnidehou, S, Francon, J, Virion, A	J. Biol. Chem.	2005