Reactome | FUT3 [Golgi membrane]

FUT3 [Golgi membrane]

Stable Identifier

R-HSA-5693934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Galactoside 3, FUT3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q12891 HYAL2

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)
        
        FUT3 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21217 FUT3

Gene Names

FUT3, FT3B, LE

Chain

chain:1-361

Reference Genes

BioGPS Gene:2525 FUT3

COSMIC (genes):FUT3 FUT3

CTD Gene:2525 FUT3

dbSNP Gene:2525 FUT3

ENSEMBL:ENSG00000171124 FUT3

HGNC:4014 FUT3

KEGG:hsa:2525 FUT3

Monarch:2525 FUT3

NCBI Gene:2525 FUT3

OMIM:111100 FUT3

UCSC:P21217 FUT3

Reference Transcript

Other Identifiers

11728007_x_at

11728008_x_at

11739970_a_at

16867572

214088_PM_s_at

214088_s_at

216010_PM_x_at

216010_x_at

2525

36290_s_at

3847469

3847470

3847471

3847485

3847487

3847488

3847489

3847490

3847491

3847492

3847493

3847494

3847495

3847496

3847497

3847498

3847499

3847500

3847502

3847505

3847506

3847507

38495_s_at

3907071

8033054

A_23_P360316

GE80896

GO:0000139

GO:0003824

GO:0005515

GO:0005794

GO:0005975

GO:0006486

GO:0006487

GO:0006493

GO:0006629

GO:0006672

GO:0008417

GO:0009311

GO:0009312

GO:0009988

GO:0016020

GO:0016740

GO:0016757

GO:0017060

GO:0017083

GO:0022409

GO:0030334

GO:0032580

GO:0036065

GO:0042127

GO:0043226

GO:0043413

GO:0046920

GO:0070062

HMNXSV003043412

HMNXSV003056896

Hs.169238.3.A1_3p_a_at

ILMN_1653358

PH_hs_0010092

PH_hs_0030735

S52969_cds1_s_at

TC19001085.hg

U27326_s_at

U27333_s_at

g182491_3p_s_at

g967208_3p_s_at

Participates

as a member of

FUT3,5,6,7 [Golgi membrane] (Homo sapiens)

Inferred To

fut4 [Golgi membrane] (Dictyostelium discoideum)

fut-3 [Golgi membrane] (Caenorhabditis elegans)

fut11 [Golgi membrane] (Dictyostelium discoideum)

fut1 [Golgi membrane] (Dictyostelium discoideum)

LOC100513844 [Golgi membrane] (Sus scrofa)

FUT3 [Golgi membrane] (Bos taurus)

FUT3 [Golgi membrane] (Caenorhabditis elegans)

LOC100485897 [Golgi membrane] (Xenopus tropicalis)

fut2 [Golgi membrane] (Dictyostelium discoideum)

Homologues of FUT3 [Golgi membrane] (Caenorhabditis elegans)

Homologues of FUT3 [Golgi membrane] (Dictyostelium discoideum)

Homologues of FUT3 [Golgi membrane] (Xenopus tropicalis)

fut6 [Golgi membrane] (Dictyostelium discoideum)

fut6 [Golgi membrane] (Xenopus tropicalis)

fut10 [Golgi membrane] (Dictyostelium discoideum)

fut5 [Golgi membrane] (Dictyostelium discoideum)

FUT5 [Golgi membrane] (Canis familiaris)

fut3 [Golgi membrane] (Dictyostelium discoideum)

fut3 [Golgi membrane] (Xenopus tropicalis)

pha-1 [Golgi membrane] (Caenorhabditis elegans)

fut6.2 [Golgi membrane] (Xenopus tropicalis)

fut7 [Golgi membrane] (Dictyostelium discoideum)

FucTA [Golgi membrane] (Drosophila melanogaster)

fut9 [Golgi membrane] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000171124

ENSEMBL

ENSP00000517813, ENST00000709634, ENST00000589620, ENST00000458379, ENST00000709637, ENSP00000517811, ENSP00000517814, ENSP00000517812, ENST00000303225, ENSP00000416443, ENST00000589918, ENSP00000465804, ENSP00000305603, ENSP00000468123, ENST00000709635, ENST00000709636

HPA

ENSG00000171124-FUT3

PRO

P21217

Pharos - Targets

P21217

GlyGen

P21217

HMDB Protein

HMDBP11739

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P58499 FAM3B			0.666	4
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:Q96JW4 SLC41A2	1	SLC41A2 [plasma membrane] (R-HSA-442666)	0.556	3
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [secretory granule membrane] (R-HSA-437105) SLC30A5 [Golgi membrane] (R-HSA-9817559)	0.527	2
UniProt:O75973 C1QRF			0.527	2
UniProt:Q96S86 HPLN3			0.527	2
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.527	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	2
UniProt:P05496 ATP5MC1	5	ATP5G1(1-136) [mitochondrial inner membrane] (R-HSA-1299432) ATP5G1(1-61) [mitochondrial matrix] (R-HSA-8986143) ATP5G1(1-136) [mitochondrial intermembrane space] (R-HSA-1267972) ATP5G1(1-136) [cytosol] (R-HSA-1267993) ATP5MC1 [mitochondrial inner membrane] (R-HSA-164535)	0.527	2
UniProt:Q8IW92 GLB1L2	1	GLB1L2 [lysosomal lumen] (R-HSA-9840308)	0.527	2

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