Reactome | PXLP-K280-SHMT2 [mitochondrial inner membrane]

PXLP-K280-SHMT2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5694086

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Serine hydroxymethyltransferase, mitochondrial, GLYM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34897 SHMT2

Gene Names

SHMT2

Chain

transit peptide:1-29, chain:30-504

Reference Genes

BioGPS Gene:6472 SHMT2

COSMIC (genes):SHMT2 SHMT2

CTD Gene:6472 SHMT2

dbSNP Gene:6472 SHMT2

ENSEMBL:ENSG00000182199 SHMT2

HGNC:10852 SHMT2

Monarch:6472 SHMT2

NCBI Gene:6472 SHMT2

OMIM:138450 SHMT2

UCSC:P34897 SHMT2

Reference Transcript

Other Identifiers

11746438_a_at

11747537_x_at

11750992_x_at

11756615_x_at

16752834

214095_PM_at

214095_at

214096_PM_s_at

214096_s_at

214437_3p_s_at

214437_PM_s_at

214437_s_at

3418008

3418009

3418010

3418011

3418012

3418013

3418014

3418015

3418016

3418017

3418018

3418019

3418020

3418021

3418022

3418023

3418024

3418025

3418026

3418027

3418028

3418029

3418030

3418031

3418032

3418033

3418034

3418035

3418036

3418037

3418038

3418039

3418040

3418041

3418042

36178_at

6472

7956401

A_14_P122852

A_23_P158239

A_23_P169629

GE59018

GO:0002082

GO:0003682

GO:0003824

GO:0004372

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005856

GO:0006520

GO:0006544

GO:0006545

GO:0006563

GO:0006564

GO:0006565

GO:0006575

GO:0006730

GO:0006766

GO:0008168

GO:0008270

GO:0008284

GO:0008732

GO:0015630

GO:0016597

GO:0016740

GO:0016829

GO:0019264

GO:0030170

GO:0032259

GO:0034340

GO:0035999

GO:0042645

GO:0042802

GO:0043226

GO:0046653

GO:0046655

GO:0050897

GO:0051262

GO:0051289

GO:0065003

GO:0070062

GO:0070129

GO:0070536

GO:0070552

GO:0070905

GO:1903715

HMNXSV003011419

Hs.2186.4.A1_3p_a_at

Hs.2186.4.A1_3p_x_at

Hs.75069.0.S1_3p_x_at

ILMN_1661264

PH_hs_0004269

PH_hs_0031312

TC12000525.hg

TC12002398.hg

U23143_at

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as a component of

PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

SHMT2 [cytosol]

Inferred To

Shmt2 [mitochondrial inner membrane] (Mus musculus)

Shmt2 [mitochondrial inner membrane] (Rattus norvegicus)

Homologues of PXLP-K280-SHMT2 [mitochondrial inner membrane] (Plasmodium falciparum)

PXLP-K280-SHMT2 [mitochondrial inner membrane] (Plasmodium falciparum)

shmt2 [mitochondrial inner membrane] (Danio rerio)

shmt2 [mitochondrial inner membrane] (Xenopus tropicalis)

SHMT2 [mitochondrial inner membrane] (Bos taurus)

SHMT2 [mitochondrial inner membrane] (Canis familiaris)

SHMT2 [mitochondrial inner membrane] (Sus scrofa)

shmt1 [mitochondrial inner membrane] (Dictyostelium discoideum)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 280

Coordinate

280

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

OpenTargets

ENSG00000182199

ENSEMBL

ENST00000553474, ENST00000328923, ENSP00000452419, ENST00000449049, ENST00000557487, ENST00000414700, ENSP00000413770, ENSP00000452315, ENSP00000406881, ENSP00000333667

HPA

ENSG00000182199-SHMT2

PRO

P34897

Pharos - Targets

P34897

GlyGen

P34897

HMDB Protein

HMDBP00792

PDB

8QI7, 8SSJ, 5X3V, 8T4P, 8GKW, 7BYI, 8GKT, 6QVL, 6M5O, 6R8F, 8AQL, 8FJT, 6H3C, 8GKS, 8GKZ, 8GKY, 8T4O, 5V7I, 4PVF, 6QVG, 8GKU, 8TLC, 8FJU, 6DK3

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46736 BRCC3	2	BRCC3 [cytosol] (R-HSA-5691415) BRCC3 [nucleoplasm] (R-HSA-5682577)	0.723	4
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.643	4
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10