Reactome | NT5C3B hydrolyses 7MGP to 7MG

NT5C3B hydrolyses 7MGP to 7MG

Stable Identifier

R-HSA-5694126

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) specifically hydrolyses N(7)-methylguanosine monophosphate (7MGMP) to 7-methylguanosine (7MG) and inorganic phosphate (Pi). 7MGP is a modified nucleotide byproduct of mRNA turnover and requires degradation as its incorporation into nucleic acids is undesirable (Buschmann et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23223233	Identification of Drosophila and human 7-methyl GMP-specific nucleotidases Schierhorn, A, Lilie, H, Moritz, B, Wahle, E, Jeske, M, Buschmann, J	J. Biol. Chem.	2013