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EPHX1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5694132
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Epoxide hydrolase 1 ecNumber3.3.2.9/ecNumber, HYEP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)
EPHX1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07099 EPHX1
Gene Names
EPHX1, EPHX, EPOX
Chain
chain:1-455
Reference Genes
BioGPS Gene:2052 EPHX1
COSMIC (genes):EPHX1 EPHX1
CTD Gene:2052 EPHX1
dbSNP Gene:2052 EPHX1
ENSEMBL:ENSG00000143819 EPHX1
HGNC:3401 EPHX1
Monarch:2052 EPHX1
NCBI Gene:2052 EPHX1
OMIM:132810 EPHX1
UCSC:P07099 EPHX1
Reference Transcript
RefSeq:NM_001136018.3 EPHX1
RefSeq:NM_001291163.1 EPHX1
RefSeq:NM_000120.3 EPHX1
Other Identifiers
11741065_a_at
16678114
202017_PM_at
202017_at
2052
2382894
2382971
2382972
2382973
2382974
2382976
2382979
2382980
2382981
2382986
2382987
2382988
2382993
2382996
2382997
2382998
38790_at
59694_at
7910111
A_14_P138423
A_23_P34537
GE57696
GE58208
GO:0003824
GO:0004301
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0006805
GO:0008142
GO:0008289
GO:0009056
GO:0009636
GO:0014070
GO:0016020
GO:0016787
GO:0016803
GO:0019369
GO:0033961
GO:0043226
GO:0097176
HMNXSV003031758
ILMN_1701025
L25878_s_at
PH_hs_0005010
TC01001856.hg
g4557560_3p_at
Inferred To
EPHX1 [endoplasmic reticulum membrane]
(Bos taurus)
EPHX1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
EPHX1 [endoplasmic reticulum membrane]
(Canis familiaris)
EPHX1 [endoplasmic reticulum membrane]
(Sus scrofa)
Jheh3 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Jheh2 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Jheh1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of EPHX1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of EPHX1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of EPHX1 [endoplasmic reticulum membrane]
(Sus scrofa)
EPHX1L [endoplasmic reticulum membrane]
(Gallus gallus)
Ephx1 [endoplasmic reticulum membrane]
(Mus musculus)
Ephx1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000355802
,
ENSP00000480004
,
ENST00000366837
,
ENST00000272167
,
ENSP00000272167
,
ENST00000614058
OpenTargets
ENSG00000143819
ZINC - Substances
HYEP_HUMAN
ZINC - Biogenic
HYEP_HUMAN
ZINC target
P07099
PRO
P07099
GlyGen
P07099
ZINC - Metabolites
HYEP_HUMAN
IntEnz
3.3.2.9
HPA
ENSG00000143819-EPHX1
Pharos - Targets
P07099
Orphanet
EPHX1
ZINC - Predictions - Purchasable
HYEP_HUMAN
HMDB Protein
HMDBP01791
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23560-2 BDNF
0.556
3
UniProt:O43291 SPINT2
1
SPINT2 [extracellular region]
(R-HSA-6800233)
0.527
2
UniProt:Q96FV3 TSN17
0.527
2
UniProt:Q9BQ31 KCNS3
1
KCNS3 [plasma membrane]
(R-HSA-381709)
0.527
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.527
2
UniProt:Q8NHS3 MFSD8
0.527
3
UniProt:Q9Y5M8 SRPRB
1
SRPRB [endoplasmic reticulum membrane]
(R-HSA-265002)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.519
5
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
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