NSF and SNAPs bind cis-SNARE complex

Stable Identifier
R-HSA-5694423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009).
Literature References
PubMed ID Title Journal Year
8620540 Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles

Haas, A, Mayer, A, Wickner, W

Cell 1996
8221884 A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

Söllner, T, Whiteheart, SW, Scheller, RH, Bennett, MK, Rothman, JE

Cell 1993
19164740 Membrane fusion: grappling with SNARE and SM proteins

Südhof, TC, Rothman, JE

Science 2009
16912714 SNAREs--engines for membrane fusion

Scheller, RH, Jahn, R

Nat. Rev. Mol. Cell Biol. 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!