Reactome | MIA3 binds procollagen VII

MIA3 binds procollagen VII

Stable Identifier

R-HSA-5694427

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        MIA3 binds procollagen VII (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Procollagen VII trimers, which are too large for standard COPII vesicles, are packaged into larger transport vesicles through interaction with the transmembrane accessory proteins MIA3 (also known as TANGO1) and MIA2 (also known as CTAGE5). MIA3 interacts with collagen through its lumenal SH3 domain and interacts with SEC23 and SEC24 through the proline rich domain (Saito et al, 2009; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
21878990	Protein export at the ER: loading big collagens into COPII carriers Malhotra, V, Erlmann, P	EMBO J	2011
25619253	Procollagen export from the endoplasmic reticulum Erlmann, P, Nogueira, C, Malhotra, V	Biochem. Soc. Trans.	2015
19269366	TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites Polischuk, R, Saito, K, Chen, M, Schekman, R, Chen, S, Bard, F, Woodley, D, Malhotra, V, Zhou, H	Cell	2009