Reactome | ALDH1B1 tetramer oxidises CH3CHO to CH3COOH

ALDH1B1 tetramer oxidises CH3CHO to CH3COOH

Stable Identifier

R-HSA-5696091

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ALDH1B1 tetramer oxidises CH3CHO to CH3COOH

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ethanol-induced organ damage is attributed to its toxic metabolite acetaldehyde (CH3CHO) therefore metabolism and elimination of this metabolite is important for cellular defence. Mitochondrial ALDH1B1 is one of several human ALDHs that can oxidise CH3CHO to acetic acid (CH3COOH) (Stagos et al. 2010). ALDH1B1 is thought to function as a homotetramer.

Literature References

PubMed ID	Title	Journal	Year
20616185	Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme Jackson, BC, Orlicky, DJ, Brocker, C, Stagos, D, Vasiliou, V, Thompson, DC, Donald, E, Chen, Y	Drug Metab. Dispos.	2010