Reactome | ACSS3 [mitochondrial matrix]

ACSS3 [mitochondrial matrix]

Stable Identifier

R-HSA-5696385

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Acyl-CoA synthetase short-chain family member 3, mitochondrial ecNumber6.2.1.1/ecNumber, ACSS3_HUMAN

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (Homo sapiens)
        
        ACSS3 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H6R3 ACSS3

Gene Names

ACSS3

Chain

transit peptide:1-29, chain:30-686

Reference Genes

BioGPS Gene:79611 ACSS3

COSMIC (genes):ACSS3 ACSS3

CTD Gene:79611 ACSS3

dbSNP Gene:79611 ACSS3

ENSEMBL:ENSG00000111058 ACSS3

HGNC:24723 ACSS3

KEGG:hsa:79611 ACSS3

Monarch:79611 ACSS3

NCBI Gene:79611 ACSS3

OMIM:614356 ACSS3

UCSC:Q9H6R3 ACSS3

Reference Transcript

Other Identifiers

11730931_at

11730932_at

11759049_at

16754729

219616_PM_at

219616_at

229222_PM_at

229222_at

3424207

3424208

3424209

3424224

3424225

3424226

3424229

3424233

3424234

3424235

3424236

3424237

3424242

3424243

3424244

3424245

3424250

3424251

3424252

3424255

3424259

3424260

3424261

3424266

3424267

3424269

3424270

3424271

3424272

3424274

3424276

3424278

3424280

50888_at

62715_at

63213_at

7957386

79611

A_14_P100120

A_14_P106023

A_14_P126941

A_23_P339119

A_24_P99005

GE866295

GE87323

GO:0000166

GO:0003824

GO:0003987

GO:0005515

GO:0005524

GO:0005739

GO:0005759

GO:0006091

GO:0006629

GO:0016874

GO:0031956

GO:0043226

GO:0043231

GO:0046951

GO:0050218

GO:0140657

HMNXSV003030436

HMNXSV003038839

HMNXSV003045567

Hs.16602.0.A1_3p_at

ILMN_1659885

PH_hs_0001268

PH_hs_0038375

TC12000672.hg

g13375726_3p_at

Participates

as an output of

ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (Homo sapiens)

Inferred To

Dmel\CG6432 [mitochondrial matrix] (Drosophila melanogaster)

acss3 [mitochondrial matrix] (Xenopus tropicalis)

ACSS3 [mitochondrial matrix] (Bos taurus)

ACSS3 [mitochondrial matrix] (Canis familiaris)

ACSS3 [mitochondrial matrix] (Gallus gallus)

ACSS3 [mitochondrial matrix] (Mus musculus)

ACSS3 [mitochondrial matrix] (Rattus norvegicus)

ACSS3 [mitochondrial matrix] (Sus scrofa)

aslB [mitochondrial matrix] (Dictyostelium discoideum)

Cross References

ENSEMBL

ENST00000548058, ENSP00000449535, ENSG00000111058

OpenTargets

ENSG00000111058

IntEnz

6.2.1.17

GeneCards

ACSS3

HPA

ENSG00000111058-ACSS3

PRO

Q9H6R3

Pharos - Targets

Q9H6R3

GlyGen

Q9H6R3

HMDB Protein

HMDBP11602

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3