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Global Genome Nucleotide Excision Repair (GG-NER)
Stable Identifier
R-HSA-5696399
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
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The DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex, is an ubiquitin ligase composed of DDB1, CUL4A or CUL4B, RBX1 and a GG-NER specific protein DDB2. In vitro, the UV-DDB complex is onlynecessary for GG-NER mediated repair of UV-induced pyrimidine dimers. In vivo, however, where DNA repair occurs in the chromatin context, the UV-DDB complex likely facilitates GG-NER mediated repair irrespective of the DNA damage type.
After DNA damage recognition, the TFIIH complex, together with XPA, verifies the DNA damage and unwinds the DNA helix around the damage, creating an open bubble. Two DNA endonucleases, ERCC5 (XPG) and the complex of ERCC1 and ERCC4 (XPF), excise the oligonucleotide that contains damaged base(s) from the affected DNA strand. DNA polymerases delta, epsilon and/or kappa perform DNA repair synthesis, followed by DNA ligation, thus completing GG-NER.
For a recent review, please refer to Marteijn et al. 2014.
Literature References
PubMed ID
Title
Journal
Year
24954209
Understanding nucleotide excision repair and its roles in cancer and ageing
Lans, H
,
Marteijn, JA
,
Hoeijmakers, JH
,
Vermeulen, W
Nat. Rev. Mol. Cell Biol.
2014
Participants
Events
DNA Damage Recognition in GG-NER
(Homo sapiens)
Formation of Incision Complex in GG-NER
(Homo sapiens)
Dual Incision in GG-NER
(Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER
(Homo sapiens)
Participates
as an event of
Nucleotide Excision Repair (Homo sapiens)
Event Information
Go Biological Process
global genome nucleotide-excision repair (0070911)
Orthologous Events
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Gallus gallus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Plasmodium falciparum)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Saccharomyces cerevisiae)
Global Genome Nucleotide Excision Repair (GG-NER) (Schizosaccharomyces pombe)
Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2015-05-28)
Gopinathrao, G (2004-02-02)
Hoeijmakers, JH (2004-01-29)
Reviewed
Fousteri, M (2015-08-03)
Created
Orlic-Milacic, M (2015-05-28)
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