AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters

Stable Identifier
R-HSA-5696424
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Arachidyl alcohol (ARACOH) is straight-chain fatty alcohol of C20 length used as an emollient in cosmetics. Esterification of alcohols with fatty acids represents the formation of both storage and cytoprotective molecules in the body. Overproduction of these esters is associated with several disease pathologies, including atherosclerosis and obesity. The ER membrane-associated acyl-CoA wax alcohol acyltransferase 1 (AWAT1) mediates the esterification of its preferred substrate ARACOH (Turkish et al. 2005).
Literature References
PubMed ID Title Journal Year
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM

J. Biol. Chem. 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

long-chain-alcohol O-fatty-acyltransferase activity of AWAT1 [endoplasmic reticulum membrane]

Physical Entity
AWAT1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain-alcohol O-fatty-acyltransferase activity (GO:0047196)
Orthologous Events
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Caenorhabditis elegans)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Gallus gallus)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)
AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-29)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-29)
Cite Us!