Cardiotrophin-1 (CTF1/CT-1) is a member of the IL-6 family of cytokines which was originally discovered as a factor which can induce hypertrophy of cardiac myocytes both in vitro and in vivo (Pennica et al. 1995a). Subsequently, CTF1 has been shown to have a wide variety of different effects on cardiac and non cardiac cells including the ability to stimulate the survival of both cardiac and neuronal cells (Latchman 1999). Leukemia inhibitory factor (LIF), CTF1, and oncostatin M (OSM) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp130 and LIF receptor (LIFR) (Pennica et al. 1995b).
Chien, KR, Luoh, SM, King, KL, Luis, E, Darbonne, WC, Shaw, KJ, Yen, R, Pennica, D, Rullamas, J, Knutzon, DS
Cataliotti, A, Tsuruda, T, Burnett, JC, Huntley, BK, Lee, SC, D'Assoro, AB, Chen, HH, Boerrigter, G, Larsen, AM, Jougasaki, M
Zioncheck, KA, Wood, WI, Shelton, DL, Moore, MW, Shaw, KJ, Swanson, TA, Paoni, NF, Pennica, D, Taga, T, Rosenthal, A
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