Reactome | USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1

USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1

Stable Identifier

R-HSA-5696600

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1

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USP17 regulates cell proliferation by deubiquitinating and inhibiting RCE1, which influences the localization and activation of the small GTPases NRAS and HRAS (Burrows et al. 2009). In addition, USP17 mediates deubiquitination of CDC25A, which prevents CDC25A degradation by the proteasome during the G1/S and G2/M phases, promoting cell-cycle progression (Pereq et al. 2010). USP17 cleaves Lys-48 and Lys-63-linked polyubiquitin chains from the cytoplasmic innate immune receptors DDX58 (RIG-I) and IFIH1 (MDA5), which increases activation of the IFN-beta promoter, part of the cellular response to viral infection (Chen et al. 2010). USP17 expression is upregulated by interleukin-4 and interleukin-6 (Burrows et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
20368735	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling Shu, HB, Liu, Y, Tan, B, Chen, R, Zhang, L, Zhong, B	Cell Res.	2010
19188362	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity McFarlane, C, Scott, CJ, De la Vega, M, Johnston, JA, McGrattan, MJ, Kelvin, AA, Burden, RE, Govender, U, Dib, K, Quinn, DJ, Burrows, JF, Gadina, M	J. Biol. Chem.	2009
20228808	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A O'Rourke, KM, Pereg, Y, Komuves, L, French, DM, Dey, A, Liu, BY, Sagolla, M, Dixit, VM	Nat. Cell Biol.	2010