Reactome | RTCB [nucleoplasm]

RTCB [nucleoplasm]

Stable Identifier

R-HSA-5696792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"tRNA-splicing ligase RtcB homolog ecNumber evidence="2"6.5.1.3/ecNumber, RTCB_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y3I0 RTCB

Gene Names

RTCB, C22orf28, HSPC117

Chain

chain:1-505

Reference Genes

BioGPS Gene:51493 RTCB

COSMIC (genes):RTCB RTCB

CTD Gene:51493 RTCB

dbSNP Gene:51493 RTCB

ENSEMBL:ENSG00000100220 RTCB

ENSEMBL_homo_sapiens_GENE:ENSG00000100220.12 RTCB

HGNC:26935 RTCB

KEGG Gene (Homo sapiens):51493 RTCB

Monarch:51493 RTCB

NCBI Gene:51493 RTCB

OMIM:613901 RTCB

UCSC:Q9Y3I0 RTCB

Reference Transcript

RefSeq:NM_014306.4 RTCB

Other Identifiers

11715645_s_at

11749368_a_at

11751754_a_at

11752603_a_at

11752604_s_at

16934227

18671579

18671580

18671581

18671582

18671583

18671584

18671585

18671586

18671589

18671590

18671594

18671595

18671596

18671597

200042_PM_at

200042_at

38689_at

3958254

3958255

3958258

3958261

3958262

3958263

3958266

3958267

3958269

3958273

3958276

3958278

3958279

3958281

3958282

3958283

51493

7892757

7893297

7893619

7893700

7893816

7894188

7894903

7895016

7895031

7895090

7895846

7896069

7896324

7896608

8075585

A_23_P68889

A_23_P68892

GE60554

GO:0000166

GO:0000971

GO:0001701

GO:0001890

GO:0003723

GO:0003824

GO:0003972

GO:0005515

GO:0005525

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006388

GO:0006396

GO:0006399

GO:0008033

GO:0008092

GO:0008452

GO:0016874

GO:0016886

GO:0017166

GO:0043226

GO:0043231

GO:0046872

GO:0048856

GO:0072669

GO:0140098

HMNXSV003009254

ILMN_1795991

PH_hs_0023368

TC22000682.hg

g7657014_3p_at

Participates

as a component of

tRNA ligase complex [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_055121.1

OpenTargets

ENSG00000100220

IntEnz

6.5.1.8

HPA

ENSG00000100220-RTCB

GeneCards

Q9Y3I0

Ensembl

ENSG00000100220, ENSP00000216038, ENST00000216038

PRO

Q9Y3I0

Pharos - Targets

Q9Y3I0

HMDB Protein

HMDBP11927

PDB

8ODP, 8BTT, 8ODO, 7P3B

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.57	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.462	3