tRNA ligase complex ligates tRNA exons

Stable Identifier
R-HSA-5696816
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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tRNA ligase complex ligates tRNA exons
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The RNA ligase complex ligates tRNA exons yielding intact, spliced tRNAs (Popow et al. 2011, Popow et al. 2014). The reaction apparently occurs in one step with no residual 2' phosphate that requires removal, as in yeast.
Literature References
PubMed ID Title Journal Year
21311021 HSPC117 is the essential subunit of a human tRNA splicing ligase complex

Martinez, J, Will, CL, Lührmann, R, Trowitzsch, S, Mechtler, K, Schleiffer, A, Söll, D, Weitzer, S, Englert, M, Mierzwa, B, Popow, J

Science 2011
24870230 Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Martinez, J, Jurkin, J, Schleiffer, A, Popow, J

Nature 2014
Participants
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Output
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Event Information
Go Biological Process
tRNA splicing, via endonucleolytic cleavage and ligation (0006388)
Catalyst Activity

RNA ligase (ATP) activity of tRNA ligase complex [nucleoplasm]

Physical Entity
tRNA ligase complex [nucleoplasm] (Homo sapiens)
Activity
RNA ligase (ATP) activity (GO:0003972)
Authored
May, B  (2015-05-29)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-05-30)
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