Reactome | IDE [mitochondrial outer membrane]

IDE [mitochondrial outer membrane]

Stable Identifier

R-HSA-5696861

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
        
        USP30:MOM proteins [mitochondrial outer membrane] (Homo sapiens)
        
        MOM proteins [mitochondrial outer membrane] (Homo sapiens)
        
        IDE [mitochondrial outer membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

BioGPS Gene:3416 IDE

COSMIC (genes):IDE IDE

CTD Gene:3416 IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

ENSEMBL_homo_sapiens_GENE:ENSG00000119912.18 IDE

HGNC:5381 IDE

KEGG Gene (Homo sapiens):3416 IDE

Monarch:3416 IDE

NCBI Gene:3416 IDE

OMIM:146680 IDE

UCSC:P14735 IDE

Reference Transcript

Other Identifiers

11753919_a_at

11763184_at

16716547

203327_PM_at

203327_at

203328_PM_x_at

203328_x_at

217496_PM_s_at

217496_s_at

241300_PM_at

241300_at

31840_at

3300352

3300353

3300354

3300355

3300356

3300357

3300358

3300359

3300361

3300362

3300370

3300371

3300372

3300373

3300374

3300376

3300377

3300379

3300384

3300385

3300386

3300388

3300392

3300393

3300395

3300396

3300397

3300398

3300399

3300400

3300403

3300404

3300406

3300407

3300419

3300420

3416

43141_at

44638_at

7935027

84458_at

A_23_P63681

A_24_P928038

A_32_P19460

A_32_P19466

GE57863

GO:0000166

GO:0001618

GO:0002376

GO:0003824

GO:0004175

GO:0004222

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005777

GO:0005782

GO:0005829

GO:0005886

GO:0006091

GO:0006508

GO:0008152

GO:0008233

GO:0008237

GO:0008270

GO:0008286

GO:0009897

GO:0009986

GO:0010815

GO:0010992

GO:0016020

GO:0016323

GO:0016787

GO:0019885

GO:0023052

GO:0030163

GO:0032092

GO:0042277

GO:0042447

GO:0042802

GO:0042803

GO:0043171

GO:0043226

GO:0043559

GO:0045732

GO:0046718

GO:0046872

GO:0050435

GO:0051603

GO:0070062

GO:0097242

GO:0140036

GO:0140096

GO:0150094

GO:1901142

GO:1901143

GO:1903715

HMNXSV003010850

HMNXSV003048938

Hs.1508.0.S2_3p_at

Hs.188682.0.A1_3p_at

Hs.326641.0.A1_3p_s_at

ILMN_1769883

M21188_at

PH_hs_0011052

PH_hs_0023525

TC10001531.hg

Participates

as a candidate of

MOM proteins [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

PolyUb-IDE [mitochondrial outer membrane]

IDE [peroxisomal matrix]

IDE [cytosol]

IDE [endosome lumen]

Inferred To

ide [mitochondrial outer membrane] (Danio rerio)

ide [mitochondrial outer membrane] (Xenopus tropicalis)

IDE [mitochondrial outer membrane] (Bos taurus)

IDE [mitochondrial outer membrane] (Caenorhabditis elegans)

IDE [mitochondrial outer membrane] (Canis familiaris)

IDE [mitochondrial outer membrane] (Drosophila melanogaster)

IDE [mitochondrial outer membrane] (Gallus gallus)

IDE [mitochondrial outer membrane] (Mus musculus)

IDE [mitochondrial outer membrane] (Rattus norvegicus)

IDE [mitochondrial outer membrane] (Schizosaccharomyces pombe)

IDE [mitochondrial outer membrane] (Sus scrofa)

Cross References

RefSeq

NP_004960.2, NP_001159418.1

Guide to Pharmacology - Targets

2371

OpenTargets

ENSG00000119912

ZINC - Substances

IDE_HUMAN

ZINC target

P14735

PRO

P14735

PDB

7RZI, 2G54, 4PFC, 2JG4, 7RZH, 5WOB, 4M1C, 4IFH, 4GS8, 4DWK, 6MQ3, 5UOE, 6B3Q, 4NXO, 7K1E, 4RE9, 2YPU, 2WK3, 2G47, 3E4Z, 2WC0, 6BF9, 6BF8, 4GSC, 4PES, 2G48, 3N56, 7RZG, 3E4A, 5CJO, 4PF7, 7RZF, 3CWW, 2JBU, 3H44, 3E50, 6BF6, 4LTE, 2G56, 6EDS, 6B7Z, 6BYZ, 6B7Y, 6BF7, 7K1D, 4QIA, 2G49, 3OFI, 2WBY, 4GSF, 3HGZ, 3N57, 3QZ2, 4RAL, 4DTT, 7RZE, 4PF9, 6B70, 6BFC, 4IOF, 7K1F

GeneCards

P14735

HPA

ENSG00000119912-IDE

Ensembl

ENSG00000119912, ENST00000265986, ENSP00000265986, ENSP00000360637, ENST00000371581

Pharos - Targets

P14735

ZINC - Predictions - Purchasable

IDE_HUMAN

HMDB Protein

HMDBP10019

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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