USP28 deubiquitinates CLSPN and MYC

Stable Identifier
R-HSA-5696914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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USP28 is Involved in DNA damage induced apoptosis by specifically stabilizing and deubiquitinating proteins of the DNA damage pathway including CLSPN (Zhang et al. 2006). It also binds to the nucleoplasmic alpha isoform of Fbw7, counteracting FBW7 ubiquitin ligase activity by deubiquitinating MYC in the nucleoplasm, which reduces MYC proteasomal degradation (Popov et al. 2007).
Literature References
PubMed ID Title Journal Year
16901786 A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

Elledge, SJ, Mak, TW, Zaugg, K, Zhang, D

Cell 2006
17873522 Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

Popov, N, Schülein, C, Eilers, M, Llamazares, M, Herold, S

Cell Cycle 2007
Participants
Participates
Catalyst Activity

cysteine-type deubiquitinase activity of USP28:PolyUb-CLSPN, PolyUb-MYC [nucleoplasm]

Orthologous Events
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